Thyroid Function Changes in the Elderly and Their Relationship to Cardiovascular Health: A Mini-Review

Gerontology
Giuseppe Barbesino

Abstract

Thyroid hormones have significant effects on the cardiovascular systems. In general, hyperthyroidism is associated with an increased risk of dysrhythmias, while hypothyroidism may cause atherosclerosis. Recent large studies have sought to identify aging-associated changes in thyroid function and their relevance to cardiovascular morbidity and mortality in the elderly. Conflicting results have often been published, likely due to the heterogeneity of the studied populations. This review seeks to briefly summarize the most recent large population studies analyzing thyroid changes with aging and interpreting their effects on cardiovascular health in the elderly. Selective review of recent literature. The emerging pattern suggests a slight decrease in thyroid function in the elderly leading to slightly higher thyroid stimulating hormone (TSH) levels. However, the incidence of mild hyperthyroidism also increases, especially in populations with historical or current iodine deficiency. Large observational studies suggest that the potential harm from mild hypothyroidism seen in younger population tends to diminish in older subjects, while the harm from mild hyperthyroidism becomes more significant. A markedly increased risk of atrial fi...Continue Reading

Citations

Nov 20, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Giuseppe LiscoVincenzo Triggiani
Oct 5, 2019·Journal of Aging and Health·Paula E LesterEleanor Weinstein
Jan 14, 2020·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Helena KerpDagmar Führer
Feb 16, 2021·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Marko MilerVerica Milošević
Mar 10, 2021·Biology of Sex Differences·Shounak Baksi, Ajay Pradhan
Mar 30, 2021·International Medical Case Reports Journal·Rui HuangYuanhong Li
Jul 15, 2021·Journal of Thyroid Research·Dana M NiedowiczPeter T Nelson

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