Thyroid function in anxious and depressed patients

Pharmacopsychiatry
M L RaoK Fels

Abstract

We measured serum thyroid hormone levels, and pre- and post-TRH administration serum thyrotropin (TSH) in 46 psychiatric inpatients with major depression (n = 20), anxiety disorder (n = 9), and anxious depression (n = 17), and in 56 healthy subjects. Basal serum triiodothyronine was lower in female patients with major depression and anxious depression than in healthy women (P less than 0.05). Basal serum thyroxine was lower in female patients with anxious depression than in controls; all patients showed lower basal serum TSH than controls. In healthy subjects, basal triiodothyronine and thyroxine, basal TSH, and delta TSH (the increment of TSH after TRH administration) correlated, whereas no correlation was found between triiodothyronine and thyroxine in male patients with major depression, or between TSH and delta TSH in female patients with major depression or anxious depression. In female patients, 45% with major depression, 25% with anxiety disorder, and 35% with anxious depression showed a blunted TSH response. We also investigated pre- and post-dexamethasone administration cortisol levels in these patients. The sensitivity obtained by the combination of the results of the TRH and dexamethasone suppression tests for major ...Continue Reading

Citations

Jun 18, 1998·Journal of Affective Disorders·J Spoov, L Lahdelma
Apr 29, 2004·BMC Psychiatry·Konstantinos N FountoulakisPer Bech
Mar 16, 2013·Depression and Anxiety·Dawn F IonescuCarlos A Zarate
Jul 25, 2006·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Konstantinos N FountoulakisGeorge Kaprinis
Feb 17, 2017·Chronic Stress·Rachel A RossDawn F Ionescu
Jun 9, 2005·Annals of Clinical Psychiatry : Official Journal of the American Academy of Clinical Psychiatrists·Michael J Panzer

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