PMID: 9427898Jan 15, 1998Paper

Thyroid function in children with Cushing's disease before and after transsphenoidal surgery

The Journal of Pediatrics
Constantine A StratakisG P Chrousos

Abstract

The degree of thyroid impairment and the effects on growth have not been investigated in children with Cushing's disease. We followed the thyroid function of 24 children and adolescents (12 males and 12 females) with CD (age, 12.9 +/- 3.2 years; mean +/- SD), who were successfully treated by transsphenoidal surgery. Patients were evaluated before, and 3, 6, and 12 months after TSS. Analysis of variance and linear correlation were performed between thyroid function tests and body weight and mass index and bone age. Preoperative free thyroxine levels (1.37 +/- 0.03 ng/dl) were significantly higher than those at 3 months (1.17 +/- 0.05 ng/dl, p < 0.05), but similar to those at 6 and 12 months postoperatively. Preoperative T3 (114.2 +/- 7.7 ng/dl) and TSH (1.36 +/- 0.2 IU/ml) were significantly lower than the postoperative values at 3 (158.9 +/- 6.8 and 2.3 +/- 0.3, respectively), 6 (159.1 +/- 10.8 and 2.5 +/- 0.3, respectively), and 12 months (136 +/- 6.5 and 2.2 +/- 0.3, respectively) (all p < 0.05). One patient had frank hypothyroidism (fT4 < 1 ng/dl) before surgery. Five additional patients had secondary hypothyroidism in the immediate postsurgical period; two of them had normal thyroid function 2 and 3 years postoperatively. O...Continue Reading

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Citations

Mar 9, 2012·The Journal of Clinical Endocrinology and Metabolism·Maya LodishConstantine A Stratakis
Aug 30, 2013·European Journal of Endocrinology·Oskar Ragnarsson, Gudmundur Johannsson
Apr 4, 2002·Journal of Endocrinological Investigation·M A Magiakou, G P Chrousos
Dec 13, 2016·Reviews in Endocrine & Metabolic Disorders·Constantine A Stratakis
Dec 3, 2003·Annals of the New York Academy of Sciences·George Mastorakos, Ioannis Ilias
Apr 12, 2018·Archives of Endocrinology and Metabolism·Sema Ciftci DogansenSema Yarman
May 4, 2013·The Journal of Clinical Endocrinology and Metabolism·Margaret F Keil
May 29, 2007·Indian Journal of Pediatrics·Abolfazl Mahyar
Jun 13, 2015·Endocrine Reviews·Rosario PivonelloAnnamaria Colao
May 20, 2000·Annals of the New York Academy of Sciences·G Mastorakos, I Ilias
Nov 26, 2020·The Journal of Clinical Endocrinology and Metabolism·Skand ShekharLynnette K Nieman

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