Thyroid Function in Early Pregnancy, Child IQ, and Autistic Traits: A Meta-Analysis of Individual Participant Data

The Journal of Clinical Endocrinology and Metabolism
Deborah LevieMònica Guxens

Abstract

Low maternal free T4 (FT4) has been associated with poor child neurodevelopment in some single-center studies. Evidence remains scarce for the potential adverse effects of high FT4 and whether associations differ in countries with different iodine status. To assess the association of maternal thyroid function in early pregnancy with child neurodevelopment in countries with a different iodine status. Meta-analysis of individual participant data from 9036 mother-child pairs from three prospective population-based birth cohorts: INMA [Infancia y Medio Ambiente (Environment and Childhood project) (Spain)], Generation R (Netherlands), and ALSPAC (Avon Longitudinal Study of Parents and Children, United Kingdom). The exclusion criteria were multiple pregnancies, fertility treatments, thyroid-interfering medication usage, and known thyroid disease. Child nonverbal IQ at 5 to 8 years of age, verbal IQ at 1.5 to 8 years of age, and autistic traits within the clinical range at 5 to 8 years of age. FT4 <2.5th percentile was associated with a 3.9-point (95% CI, -5.7 to -2.2) lower nonverbal IQ and a 2.1-point (95% CI, -4.0 to -0.1) lower verbal IQ. A suggestive association of hypothyroxinemia with a greater risk of autistic traits was obser...Continue Reading

References

Feb 21, 1991·The New England Journal of Medicine·J G Thorpe-BeestonA M McGregor
Jan 1, 1994·Developmental Neuroscience·J M Pasquini, A M Adamo
Jul 22, 1998·Journal of Neuroscience Research·C B MartaJ M Pasquini
Aug 14, 1999·Thyroid : Official Journal of the American Thyroid Association·D Glinoer
Aug 19, 1999·The New England Journal of Medicine·J E HaddowR Z Klein
Aug 29, 2001·Evaluation & the Health Professions·D M Bravata, I Olkin
Jun 13, 2002·Environmental Health Perspectives·Kembra L Howdeshell
Jul 12, 2002·Statistics in Medicine·Julian P T Higgins, Simon G Thompson
May 14, 2003·Archives of General Psychiatry·John N Constantino, Richard D Todd
Dec 25, 2004·Autism : the International Journal of Research and Practice·Jo WilliamsCarol Brayne
Aug 23, 2005·Vitamins and Hormones·Juan Bernal
Dec 2, 2005·The British Journal of Psychiatry : the Journal of Mental Science·David H SkuseJane Scourfield
Apr 20, 2006·The Journal of Clinical Endocrinology and Metabolism·Roberto NegroHaslinda Hassan
Nov 1, 2008·BMC Medical Research Methodology·Ian Shrier, Robert W Platt
Dec 31, 2008·American Journal of Obstetrics and Gynecology·Richard H LeeT Murphy Goodwin
Jul 1, 2009·BMJ : British Medical Journal·Jonathan A C SterneJames R Carpenter
Dec 17, 2009·Journal of Epidemiology and Community Health·M MurciaUNKNOWN INMA Study Group
Jun 11, 2010·The Journal of Clinical Endocrinology and Metabolism·Jens HenrichsHenning Tiemeier
Jun 11, 2010·The Journal of Clinical Endocrinology and Metabolism·Roberto NegroAlex Stagnaro-Green
Apr 8, 2011·International Journal of Epidemiology·Mònica GuxensUNKNOWN INMA Project
Feb 10, 2012·The New England Journal of Medicine·John H LazarusNicholas J Wald
Apr 18, 2012·International Journal of Epidemiology·Andy BoydGeorge Davey Smith
Oct 19, 2012·The Journal of Nutrition·Nina H van MilRégine P M Steegers-Theunissen
Nov 14, 2012·Gynecologic and Obstetric Investigation·Thibault LepoutreChantal Daumerie
Aug 15, 2013·Annals of Neurology·Gustavo C RománHenning Tiemeier
Aug 5, 2014·Thyroid : Official Journal of the American Thyroid Association·Haixia LiuWeiping Teng
Jul 22, 2015·Biological Psychiatry·David GyllenbergAlan S Brown
Oct 21, 2015·Journal of Neurochemistry·Orly ReinerKozo Kaibuchi
Jan 7, 2017·Thyroid : Official Journal of the American Thyroid Association·Erik K AlexanderScott Sullivan
Jan 11, 2017·European Journal of Epidemiology·Marjolein N KooijmanVincent W V Jaddoe
Mar 2, 2017·The New England Journal of Medicine·Brian M CaseyUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network

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Citations

Jul 30, 2019·Current Opinion in Endocrinology, Diabetes, and Obesity·Freddy J K TolozaSpyridoula Maraka
Mar 18, 2020·Prenatal Diagnosis·Sawyer Huget-Penner, Denice S Feig
Feb 20, 2020·Paediatric and Perinatal Epidemiology·Gro D VillangerHeidi Aase
Aug 23, 2018·Thyroid : Official Journal of the American Thyroid Association·Marianne Hope AbelAnne Lise Brantsæter
Oct 17, 2019·JAMA Network Open·Akhgar GhassabianMònica Guxens
Aug 21, 2019·Thyroid : Official Journal of the American Thyroid Association·Deborah LevieMònica Guxens
May 22, 2020·Frontiers in Genetics·Sudipta DuttaDouglas M Ruden
Nov 24, 2020·Critical Reviews in Food Science and Nutrition·Ma Cecilia OpazoClaudia A Riedel
Nov 25, 2019·Molecular and Cellular Endocrinology·Katherine L O'Shaughnessy, Mary E Gilbert
May 1, 2021·Clinical Endocrinology·Marianne Skovsager AndersenDorte Glintborg
Sep 14, 2021·Journal of Endocrinological Investigation·A AmouzegarF Azizi
Nov 19, 2021·Endocrine Reviews·Maria Andersson, Christian P Braegger
Nov 10, 2021·American Journal of Perinatology·Anna PalatnikUNKNOWN Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units Network, Bethesda,

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