Thyroid function in epileptic patients treated with carbamazepine

Archives of Neurology
J I IsojärviV V Myllylä

Abstract

The effects of carbamazepine monotherapy on thyroid function were evaluated in patients with epilepsy. A prospective follow-up of 40 patients with recently diagnosed epilepsy was carried out to evaluate the short-term effects. Thirty-three patients receiving long-term carbamazepine therapy (average duration, 4.2 years) and 34 healthy control subjects were studied. Levels of serum thyroxine, free thyroxine, and thyroxine binding globulin were decreased after both 2 and 12 months of therapy with carbamazepine. Low serum thyroxine and free thyroxine concentrations were also found after long-term monotherapy with carbamazepine. Baseline thyrotropin did not change during carbamazepine therapy, but thyrotropin responses to thyrotropin-releasing hormone rose slightly. No correlation was found between serum carbamazepine and hormone concentrations. The results not only support previous suggestions that carbamazepine induces the hepatic clearance of thyroid hormones but also suggest that carbamazepine may have an inhibitory effect at the hypothalamic level.

Citations

Nov 6, 2008·European Journal of Endocrinology·Alberto VerrottiFrancesco Chiarelli
Jun 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·J I IsojärviV V Myllylä
Jul 1, 1991·Epilepsy Research·J I IsojärviV V Myllylä
Jan 1, 1991·European Journal of Clinical Pharmacology·P H Davies, J A Franklyn
Aug 3, 2001·Pediatric Neurology·A VerrottiF Chiarelli
Jan 1, 1994·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·S Q ZhuZ Cai
Oct 1, 1993·Clinical Endocrinology·M P Vanderpump, W M Tunbridge
Oct 6, 2015·Expert Review of Clinical Pharmacology·Sherifa Ahmed Hamed
Jan 25, 2016·Seizure : the Journal of the British Epilepsy Association·Yin-Xi ZhangMei-Ping Ding
Jul 17, 2009·Pharmacological Reports : PR·Tomasz JakubusStanisław J Czuczwar
May 21, 2011·General Hospital Psychiatry·Young-Min ParkHeon-Jeong Lee
Oct 27, 2009·Neurologic Clinics·Page B Pennell
Nov 21, 2007·Pediatric Neurology·Manuel Castro-GagoJesús Eirís-Puñal
Apr 13, 2007·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Achilleas AttilakosEustathia Katsarou
Feb 10, 2006·Clinical Biochemistry·Terje ApelandMohammad A Mansoor
Jun 1, 1993·Acta Paediatrica Japonica; Overseas Edition·A YükselA Cenani
Apr 2, 2017·Seizure : the Journal of the British Epilepsy Association·Fu-Yuan ShihMeng-Han Tsai
Mar 1, 1991·Acta Psychiatrica Scandinavica·A BocchettaM Del Zompo
Mar 30, 2002·The Journal of International Medical Research·A CayköylüR Cetinkaya
Apr 17, 2014·Journal of Child Neurology·İhsan KafadarNazan Dalgıç
Dec 21, 1995·The New England Journal of Medicine·M I Surks, R Sievert
Nov 5, 2003·Annals of Neurology·Andrew G HerzogDonald L Schomer
Sep 9, 2018·Acta Neurologica Scandinavica·Margret Jona EinarsdottirHelga Agusta Sigurjonsdottir
Sep 14, 2007·Acta Neurologica Scandinavica·J Simko, J Horacek
Aug 1, 1995·Psychiatry and Clinical Neurosciences·M KimuraY Maeoka
Jan 1, 1992·Epilepsia·J I IsojärviV V Myllylä
Jul 15, 2004·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·D BonguU M Kabadi

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