PMID: 589803Nov 1, 1977

Thyroid function in normal subjects in Iceland and Northeast Scotland

Clinical Endocrinology
A J HedleyR HALL

Abstract

A comparative study was made of thyroid function in samples of 'well' subjects, from separate geographical areas with dissimilar dietary iodine levels. In the area with the higher iodine level, Iceland, the prevalence of positive thyroid antibody tests and serum thyrotrophin levels were lower, while the capacity of the thyroid to respond to exogenous thyrotrophin was higher than in NE Scotland, an area with lower iodine levels. In contrast the prevalence of positive tests for another organ-specific antibody, gastric parietal cell antibody, was higher in Iceland. These observations are consistent with the reported differences in the incidence rates for thyrotoxicosis and gastric carcinoma in the areas studied. The results are in agreement with our findings in two groups of post-thyroidectomy patients from the same populations. This study provides support for the view that differences in the prevalence of constitutional and environmental factors in different populations contribute to the variation in reported outcome of treatment for thyroid disease.

References

Nov 1, 1977·Clinical Endocrinology·B ThjodleifssonR HALL
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Citations

Mar 1, 1979·Clinics in Endocrinology and Metabolism·E D Williams
Jul 1, 1981·Clinics in Endocrinology and Metabolism·E D Williams
Nov 1, 1977·Clinical Endocrinology·B ThjodleifssonR HALL
Dec 17, 1977·British Medical Journal
Jun 1, 1983·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·R GärtnerH Schatz
Dec 29, 2000·Thyroid : Official Journal of the American Thyroid Association·P LaurbergL Ovesen
Nov 1, 1994·Scandinavian Journal of Gastroenterology·H ThorsB Thjodleifsson
May 31, 1980·The Medical Journal of Australia·M P BarbatoR L Kirk

Related Concepts

Autoantibodies
Diet
Stomach
Protein-Bound Iodine Test
Thyroid Gland
Thyrotropin

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