PMID: 2112071Apr 1, 1990Paper

Thyroid function in patients with myotonic dystrophy

Clinical Endocrinology
H FukazawaK Yoshinaga

Abstract

In order to investigate endocrine disturbances in patients with myotonic dystrophy (MD), 12 patients and 20 normal controls were studied. All patients were clinically euthyroid and there were no significant differences between circulating levels (mean +/- SD) of T4 (114.7 +/- 26.8 vs 129.9 +/- 28.3 nmol/l), FT4 (16.6 +/- 4.5 vs 18.4 +/- 3.8 pmol/l), T3 (1.61 +/- 0.29 vs 1.86 +/- 0.33 pmol/l), TSH (2.7 +/- 1.3 vs 2.4 +/- 1.4 mU/l), TBG (26.7 +/- 5.5 vs 27.6 +/- 4.9 mg/l), T4/T3 (84.3 +/- 18.4 vs 82.1 +/- 15.3), and FT4/FT3 (0.28 +/- 0.05 vs 0.33 +/- 0.08). Serum FT3 (4.3 +/- 1.4 pmol/l) in patients were significantly lower than those (5.3 +/- 0.9 pmol/l) in normal controls (P less than 0.02). Thyroidal 131I-uptakes (8.7 +/- 4.3%) in patients were significantly lower than those (25.8 +/- 7.4%) in controls (P less than 0.01). The mean maximal TSH responses following TRH stimulation were significantly less in patients with MD (11.4 +/- 4.5 vs 17.0 +/- 6.2 mU/l; P less than 0.02). Neither circulating thyroid microsomal nor thyroglobulin antibodies were detectable in the 11 patients tested. Serum thyroglobulin concentrations were within the normal range in all patients but one. In conclusion, it is suggested that normal levels of ser...Continue Reading

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Citations

Feb 22, 2012·Journal of Neurology·M C ØrngreenJ Vissing
May 1, 1994·Journal of the Neurological Sciences·J E AndersonL J Murphy
Nov 1, 1994·Journal of Medical Genetics·C DaumerieC Verellen-Dumoulin
Sep 21, 2002·The American Journal of the Medical Sciences·Ki-ichi OkumuraToshihiko Inukai
Jan 13, 2012·Mayo Clinic Proceedings·Aung Ko WinNoralane M Lindor
Aug 27, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J R DahlqvistJ Vissing
Feb 18, 2017·Neurologia i neurochirurgia polska·Katarzyna Kapica-TopczewskaAlina Kułakowska
Jun 19, 2018·Frontiers in Physiology·Flavia F BloiseTania M Ortiga-Carvalho

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