Thyroid function is associated with insulin resistance markers in healthy adolescents with risk factors to develop diabetes

Diabetology & Metabolic Syndrome
José de Jesús Garduño-GarciaHugo Mendieta-Zerón

Abstract

The prevalence of obesity and Type 2 diabetes mellitus (T2DM) among children and adolescents is rising. Thyroid function has been associated with insulin resistance. There is scarce information about how thyroid function could be related with cardiovascular risk or glucose homeostasis in adolescent. To analyze how thyroid function is associated with insulin resistance and another cardiovascular risk factors in healthy adolescents with risk factors to develop diabetes. A prospective cross-sectional analysis was carried out on euthyroid, adolescents. considered at high risk to develop Type 2 diabetes. Fasting blood samples were obtained. Thyroid function test and another cardiometabolic parameters were assessed. A 75 grams oral glucose tolerance test was performed to calculate insulin resistance. One hundred adolescents were evaluated. The mean age was 15.9 ± 0.8 years, There is a negative correlation between Fasting insulin, post glucose load insulin and HOMA IR. There were no correlation with Matsuda index. We could not found any correlation with TSH values. We found a correlation between fasting insulin, HOMA IR and serum thyroid hormones, we did not find any relation with serum TSH. In euthyroid adolescents with risk factors ...Continue Reading

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Citations

Sep 8, 2016·Thyroid : Official Journal of the American Thyroid Association·Trang N LeEdmond P Wickham
May 30, 2021·The Journal of Clinical Endocrinology and Metabolism·Aya BardugoGilad Twig
Aug 11, 2021·Experimental and Therapeutic Medicine·Roxana Adriana StoicaConstantin Ionescu-Tîrgoviște
Sep 16, 2021·Hormone Molecular Biology and Clinical Investigation·Niranjan GopalAshok Kumar Ahirwar

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