Thyroid Gland 18 F-FDG Uptake in Neurofibromatosis Type 1

European Thyroid Journal
Zoë Y G J van LieropMarinus J P G van Kroonenburgh

Abstract

To investigate thyroid gland characteristics on 18F-FDG positron emission tomography/computed tomography (PET/CT) imaging in patients with neurofibromatosis type 1 (NF1). Thyroid gland characteristics of patients with a clinical diagnosis of NF1 who underwent 18F-FDG PET/CT imaging for the first time to distinguish benign neurofibroma from malignant peripheral nerve sheath tumor (MPNST) at our institution (n = 69) were compared to PET/CT imaging of sarcoidosis (n = 25) and early stage lung cancer (T1N0M0 tumors, n = 15) patients. Two NF1 patients (3%) showed a diffuse 18F-FDG uptake in the thyroid gland, 2 patients (3%) had an irregular uptake, and 7 patients (10%) had a focal uptake. Among the sarcoidosis patients, 1 showed a diffuse uptake (4%) and 1 had an irregular uptake (4%). In the early stage lung cancer group, 1 patient showed a diffuse uptake (7%) and 1 had a focal uptake (7%). NF1 patients had larger mean thyroid volume and mean SUVmax compared to sarcoidosis patients but not compared to early stage lung cancer patients. Four NF1 patients were diagnosed with multinodular goiter, 2 patients were diagnosed with benign chronic lymphocytic thyroiditis, 1 patient had metastasis to the thyroid, and 1 patient had medullary ...Continue Reading

References

Dec 1, 1977·Clinical Endocrinology·W M TunbridgeP A Smith
Dec 2, 1988·Deutsche medizinische Wochenschrift·C Müller-LeisseC Pöckler
Jan 1, 1997·European Radiology·R HermansA L Baert
Sep 1, 1999·American Journal of Medical Genetics·B R Korf
May 17, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Dimitrios KarantanisVal J Lowe
Jun 26, 2008·Pediatric Dermatology·Arti Nanda
Aug 12, 2009·World Journal of Surgical Oncology·Ja Seong BaeByung Joo Song
Oct 1, 2006·Biomedical Imaging and Intervention Journal·S Ahmad Sarji
Sep 27, 2012·Head and Neck Pathology·Patricia do Socorro Queiroz FeioJorge Esquiche León
May 22, 2013·Case Reports in Neurological Medicine·Junaid Nabi

❮ Previous
Next ❯

Citations

Jul 3, 2020·Pediatric Blood & Cancer·Giuseppina ZirilliMalgorzata Wasniewska
May 25, 2021·Frontiers in Endocrinology·Benjamin ChevalierMarie Christine Vantyghem

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.