Thyroid hormone administration to hypothyroid rats restores the mitochondrial membrane permeability properties

Endocrinology
Rosa A VaccaM Greco

Abstract

We have investigated the effect of thyroid hormone on the mitochondrial membrane permeability properties in a hypothyroid rat model. The role played by calcium in affecting these properties has been also examined. Cyclosporin A-sensitive mitochondrial calcium efflux, swelling, and external release of matrix proteins are events that occur normally during the permeability transition process induced by calcium loading of mitochondria. We demonstrate that these events are impaired in mitochondria isolated from the liver of hypothyroid rats, even in the presence of high calcium content. However, after thyroid hormone administration to hypothyroid rats, the mitochondrial permeability transition process in response to calcium loading is restored. Consequently, mitochondrial calcium efflux, swelling, and release of matrix proteins, like glutamate dehydrogenase, malate dehydrogenase, and aspartate aminotransferase occur. These effects are abrogated by the concomitant administration of cyclosporin A. The results of the present study suggest that hypothyroidism may be a potential source of adverse effects in patients receiving cyclosporin A.

References

Sep 1, 1975·European Journal of Biochemistry·P FeldhauR H Schirmer
Jun 1, 1977·Analytical Biochemistry·E BustamanteP L Pedersen
May 1, 1990·The American Journal of Physiology·T E Gunter, D R Pfeiffer
Feb 1, 1990·The Biochemical Journal·R P HafnerM D Brand
Jan 1, 1988·Progress in Lipid Research·F L Hoch
Oct 1, 1987·Japanese Journal of Pharmacology·T Egashira, Y Yamanaka
Sep 1, 1965·Life Sciences·R A Freedland, L Z McFarland
Apr 1, 1995·The Biochemical Journal·E J Griffiths, A P Halestrap
Apr 1, 1994·Molecular and Cellular Biochemistry·T SchnyderT Wallimann
Apr 1, 1994·Molecular and Cellular Biochemistry·E K Seppet, V A Saks
Mar 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·S O LeongE J Lee
Sep 11, 1998·Journal of Bioenergetics and Biomembranes·F GuerrieriP Cantatore
Feb 15, 2001·Journal of Molecular Endocrinology·C Wrutniak-CabelloG Cabello
Feb 28, 2002·Journal of Bioenergetics and Biomembranes·Véronique NogueiraXavier M Leverve
May 23, 2002·Biochimie·Andrew P HalestrapSamantha J Clarke
Jun 27, 2002·European Journal of Biochemistry·Ferruccio GuerrieriMargherita Greco
Nov 7, 2002·Bioscience Reports·Fernando GogliaAntonia Lanni

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Citations

Oct 26, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Garyphallia PapaioannouEkaterini Tiligada
Jun 15, 2005·Biochimica Et Biophysica Acta·Fernanda RicchelliSergio Bova
Jun 9, 2005·The Journal of Biological Chemistry·Xavier PrieurJoan C Rodríguez
Sep 3, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Einav Yehuda-ShnaidmanJacob Bar-Tana
Feb 5, 2005·Endocrinology·Einav Yehuda-ShnaidmanJacob Bar-Tana
Aug 24, 2013·Endocrine Reviews·Einav Yehuda-ShnaidmanJacob Bar-Tana

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