Thyroid hormone analogs for the treatment of dyslipidemia: past, present, and future

Current Medical Research and Opinion
Alessandro P DelitalaGiuseppe Fanciulli

Abstract

Treatment of dyslipidemia is a major burden for public health. Thyroid hormone regulates lipid metabolism by binding the thyroid hormone receptor (TR), but the use of thyroid hormone to treat dyslipidemia is not indicated due to its deleterious effects on heart, bone, and muscle. Thyroid hormone analogs have been conceived to selectively activate TR in the liver, thus reducing potential side-effects. The authors searched the PubMed database to review TR and the action of thyromimetics in vitro and in animal models. Then, all double-blind, placebo controlled trials that analyzed the use of thyroid hormone analog for the treatment of dyslipidemia in humans were included. Finally, the ongoing research on the use of TR agonists was searched, searching the US National Institutes of Health Registry and the WHO International Clinical Trial Registry Platform (ICTRP). Thyromimetics were tested in humans for the treatment of dyslipidemia, as a single therapeutic agent or as an add-on therapy to the traditional lipid-lowering drugs. In most trials, thyromimetics lowered total cholesterol, low-density lipoprotein cholesterol, and triglycerides, but their use has been associated with adverse side-effects, both in pre-clinical studies and in...Continue Reading

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Citations

Nov 16, 2019·Minerva medica·Alessandro P DelitalaGian Luca Erre
Feb 23, 2020·Journal of Clinical Medicine·Alessandro P DelitalaGiuseppe Fanciulli
Sep 15, 2018·International Journal of Clinical Practice·Alessandro P DelitalaGiuseppe Fanciulli
Dec 21, 2018·Archives of Gynecology and Obstetrics·Alessandro P DelitalaGiuseppe Delitala
Apr 10, 2020·Journal of Clinical Medicine·Alessandro P DelitalaCarlo Doria
Jul 31, 2020·Human Gene Therapy·Qing-Shuo ZhangMarkus Grompe

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