Thyroid hormone and astrocyte morphogenesis

The Journal of Endocrinology
A G Trentin

Abstract

Astrocyte cells clearly play a role in neural development, but nowadays their total action is seen as a far wider one. Recent findings consider them as stem cells, involved in the control of most facets of functional neural networks. Astrocytes play a central role in thyroid hormone metabolism in the brain, being the principal transporters of thyroxine from the blood, responsible for its conversion to 3,5,3'-triiodothyronine and hence supplying the neural tissues with the biologically active form of the hormone. Specific thyroid hormone transporters play an essential role in this regulatory system. The presence of thyroid hormone receptors has been demonstrated in cultured astrocytes. Furthermore, thyroid hormone regulates several aspects of astrocyte differentiation and maturation, including the production of extracellular matrix proteins and growth factors, and thus controls neuronal growth and neuritogenesis. Therefore, astrocytes are currently suggested as important mediators of thyroid hormone in neuronal development.

Citations

Jan 26, 2008·Cellular and Molecular Neurobiology·Cláudia Beatriz Nedel Mendes-de-AguiarAndréa Gonçalves Trentin
Nov 14, 2008·Journal of Biosciences·Pankaj Seth, Nitin Koul
Oct 24, 2008·Nature Reviews. Molecular Cell Biology·Sandra Iden, John G Collard
Jan 18, 2013·DNA and Cell Biology·Maristela Maria MartiniMarcio Alvarez-Silva
Feb 8, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Zhenzhen ZhengHuifang Shang
May 1, 2012·Journal of Thyroid Research·Nadine Correia SantosJoana Almeida Palha
Jul 19, 2011·Journal of Thyroid Research·Fabrice ChatonnetFrédéric Flamant
Aug 31, 2011·Journal of Thyroid Research·Petra MohácsikBalázs Gereben
Mar 1, 2014·Journal of Molecular Neuroscience : MN·Athanasios LourbopoulosNikolaos Grigoriadis
Dec 15, 2012·FEBS Letters·Camila Arantes HartmannFlavia Regina Souza Lima
Mar 27, 2010·General and Comparative Endocrinology·Ronald M BonettRobert J Denver
Jul 12, 2008·Surgical Neurology·Shiuh-Lin HwangKung-Shing Lee
Jun 11, 2008·Journal of Neuroscience Research·Cláudia Beatriz Nedel Mendes-de-AguiarAndréa Gonçalves Trentin
Sep 15, 2010·Journal of Neuroscience Research·Cláudia Beatriz Nedel Mendes-de-AguiarAndréa Gonçalves Trentin
Apr 22, 2009·Brain Research·Sheila Cristina de Souza MartinsVivaldo Moura-Neto
Apr 10, 2015·Journal of Neuroendocrinology·R S DezonneF C Gomes
Jun 20, 2013·Thyroid : Official Journal of the American Thyroid Association·Eduardo A AlbornozClaudia A Riedel
Mar 9, 2017·International Reviews of Immunology·María Cecilia OpazoClaudia A Riedel
Feb 11, 2015·Molecular Neurobiology·Hui MinJie Chen
Mar 16, 2018·International Journal of Preventive Medicine·Cobra PayghaniBahman Rashidi
Mar 1, 2012·Molecular Endocrinology·Frédéric PicouFrédéric Flamant
Mar 1, 2007·Expert Review of Endocrinology & Metabolism·Samantha J RichardsonBarbara A Demeneix
Jan 13, 2012·The Journal of Nutrition, Health & Aging·M MaggioG P Ceda
May 11, 2011·Cell Cycle·Christian SchachtrupKaterina Akassoglou
Jun 11, 2014·Endocrinology·Clémence DesjardinLaurent Schibler
Nov 7, 2016·Acta Neuropathologica·Peter T NelsonDavid W Fardo
Feb 24, 2019·International Journal of Molecular Sciences·Mitsuhiro MoritaMami Noda
Jul 22, 2018·Molecular and Cellular Endocrinology·Juliana Tonietto DominguesAriane Zamoner

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