Thyroid hormone biosynthesis machinery is altered in the ischemic myocardium: An epigenomic study

International Journal of Cardiology
Carolina Gil-CayuelaManuel Portolés

Abstract

Abnormal thyroid hormone (TH) metabolism is significantly associated with impaired left ventricular (LV) function and death. Although TH was traditionally thought to be produced exclusively by the thyroid gland, an increasing number of studies report TH production in other tissues. Based on these findings, we evaluated whether the genes required for TH biosynthesis are expressed in the human heart, and whether their expression is altered in patients with ischemic cardiomyopathy (ICM) and is related to epigenetic variations. Twenty-three LV tissue samples were obtained from ICM patients (n=13) undergoing heart transplantation and control donors (n=10) for RNA sequencing analysis. We increased the LV samples to 27 for the ELISA determination of total T4 and T3 tissue levels. For epigenomic studies, 850K Infinium MethylationEPIC BeadChip platform was performed. Using RNA-sequencing, we displayed the expression levels of all components required for TH biosynthesis in human heart tissue. We observed significantly altered expression of genes encoding thyroperoxidase (TPO; -2.48-fold, P<0.05) and dual oxidase 2 (2.83-fold, P<0.05), the main enzymatic system of TH production, and significant relationships between their altered expressi...Continue Reading

Citations

Mar 19, 2020·Thyroid : Official Journal of the American Thyroid Association·Sebastian NockJens Mittag
Aug 1, 2020·Frontiers in Physiology·Kaihao WangAnthony Martin Gerdes
Apr 25, 2020·International Journal of Molecular Sciences·Narcis TribulovaBarbara Szeiffova Bacova
Mar 17, 2021·JCI Insight·Ni YangD Brian Foster
Mar 2, 2021·Cell Regeneration·Stephen Cutie, Guo N Huang

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