PMID: 8591067Oct 1, 1995Paper

Thyroid hormone changes in chronic spinal cord injury

The Journal of Spinal Cord Medicine
A L Cheville, S C Kirshblum

Abstract

Spinal cord injury (SCI) impacts metabolic function and deranges various hormonal axes. Previous studies characterizing thyroid hormones in SCI reported depressed triiodothyronine (T3) and thyroxin (T4), primarily in acute tetraplegics. These studies cited an 11-13 percent incidence of low T3 syndrome (LT3S) in SCI patients, with an increased incidence in tetraplegics (20-36 percent). The purpose of this study was to evaluate thyroid function and determine the incidence and clinical relevance of LT3S in the chronic SCI population. Thyroid function tests were performed on 30 chronic SCI patients (14 tetraplegics and 16 paraplegics) and 30 age- and gender-matched controls. Mean T3 and T4 levels were significantly depressed in SCI patients relative to controls, while T3 resin uptake (T3RU) values were significantly elevated. LT3S only occurred in the SCI population with an incidence of 23.3 percent. SCI patients with LT3S did not differ significantly from those without in the level or completeness of injury, age or the interval since injury. They did, however, have co-existent pathology: decubiti, urinary tract infections, etc. When SCI patients with normal T3 were compared with controls, they still had depressed mean T3 levels. W...Continue Reading

Citations

Mar 16, 2011·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Akshata AlmadDana M McTigue
Oct 24, 2006·Clinical Endocrinology·Sheng-Dan JiangLi-Yang Dai
Sep 23, 2009·Antioxidants & Redox Signaling·Alexandra M DumitrescuSamuel Refetoff
Dec 15, 2010·Spinal Cord·S L HitzigUNKNOWN SCIRE Research Team
Aug 28, 2013·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Iosifina KarmaniolouNikolaos Arkadopoulos
Apr 30, 2020·Endocrine·Joaquin Lado-AbealAna Marcella Rivas

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