Thyroid hormone deiodination in various tissues of larval and upstream-migrant sea lampreys, Petromyzon marinus

General and Comparative Endocrinology
J Geoffrey EalesJ H Youson

Abstract

Properties and activities of four potential thyroid hormone (TH) monodeiodinating pathways (T4ORD, L-thyroxine (T4) outer-ring (5') deiodination to 3,5,3'-triiodo-L-thyronine (T3); T4IRD, T4 inner-ring (5) deiodination to 3,3',5'-triiodo-L-thyronine (reverse T3); T3ORD, T3 outer-ring deiodination to 3,5-diiodo-L-thyronine; T3IRD, T3 inner-ring deiodination to 3,3'-diiodo-L-thyronine) were studied in microsomes of liver, kidney, muscle, and intestine of unmetamorphosed larvae and nontrophic upstream-migrant (spawning-phase) sea lampreys, Petromyzon marinus. T4ORD properties (pH optimum, dithiothreitrol cofactor requirement, apparent K(m), substrate preference and potency of potential inhibitors) were similar in most respects to those described previously for teleosts. T4ORD activity was detected in all larval tissues examined and was highest in intestine. In upstream migrants, T4ORD was also greatest in intestine, but low in muscle and kidney and undetectable in liver. T3ORD activity was not found in any tissue of either developmental stage. T4IRD and T3IRD activities were negligible in larval tissues, but present in kidney and particularly intestine of upstream migrants. We conclude that depending on developmental/physiological...Continue Reading

References

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Dec 1, 1966·General and Comparative Endocrinology·E J Barrington, M Sage
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Citations

Sep 1, 2005·Thyroid : Official Journal of the American Thyroid Association·Aurea Orozco, Carlos Valverde-R
Jul 25, 2012·The Journal of Endocrinology·Veerle M Darras, Stijn L J Van Herck
Nov 6, 2004·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Johanna SherrillGeorge T F Wong
Oct 22, 2008·Genesis : the Journal of Genetics and Development·Mathilde Paris, Vincent Laudet
Aug 14, 2012·Aquatic Toxicology·Chengyong HeChonggang Wang
Apr 10, 2008·General and Comparative Endocrinology·Lidia Mayorga MartínezCarlos Valverde-R
Mar 9, 1999·General and Comparative Endocrinology·J L Hugenberger, P Licht
Mar 19, 2004·General and Comparative Endocrinology·Margareta SutijaJean M P Joss
Nov 14, 2000·The Journal of Experimental Zoology·J M McLeeseJ G Eales
Sep 10, 2005·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·M Sutija, J M P Joss
Sep 28, 2000·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·A OrozcoC Valverde

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