Thyroid Hormone in Hepatocellular Carcinoma: Cancer Risk, Growth Regulation, and Anticancer Drug Resistance

Frontiers in Medicine
Yang-Hsiang LinChau-Ting Yeh

Abstract

Thyroid hormone (TH) and its receptor (TR) are involved in differentiation, metabolic process, and growth regulation in hepatocellular carcinoma (HCC). The TH/TR complexes are ligand-dependent transcriptional factors, functioning through binding to thyroid hormone response elements (TREs) upstream of the target genes. To date, deciphering the biological effects of TH in cancer progression remains challenging. Several lines of evidence suggest a growth inhibitory effect of TH in liver cancer. Mutation and aberrant expression of TRs are highly correlated with several types of cancers including HCC. Several reports show that TH inhibits cell growth in liver cancer through regulation of cell-cycle-related genes and non-coding RNAs. A case-control study indicates that hypothyroidism is associated with an increased risk of HCC. Moreover, TH/TR suppresses hepatocarcinogenesis via selective autophagy. Conversely, other groups have indicated that TH promotes cancer cell proliferation. In vitro and in vivo experiments show that TH/TR enhances cancer cell migration and invasion, anticancer drug resistance, angiogenesis, and cancer stem cell self-renewal. Adding to the complexity of this issue, non-genomic effects of TH mediated by integri...Continue Reading

References

Jun 1, 1997·Annals of Medicine·P P Smyth
Sep 23, 1997·Biochemical and Biophysical Research Communications·K LinS Cheng
Jan 7, 2000·The American Journal of Pathology·F DombrowskiP Bannasch
Jul 20, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Tim MitinDavid J Greenblatt
Apr 1, 2006·Endocrinology·Amedeo ColumbanoGiovanna M Ledda-Columbano
Sep 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Yukio HiroiJames K Liao
Feb 22, 2007·The Journal of Biological Chemistry·Lara F R VelascoFrancisco A R Neves
Mar 11, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Linda C HallNan Liu
Apr 25, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrea PerraAmedeo Columbano
Dec 31, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Andrea PerraAmedeo Columbano
Jan 17, 2009·Cancer Research·Olaia Martínez-IglesiasAna Aranda
Apr 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Manal M HassanJames L Abbruzzese
May 9, 2009·Molecular and Cellular Endocrinology·Chen-Shin LiaoKwang-Huei Lin
Jul 31, 2009·PloS One·Olaia Martínez-IglesiasAna Aranda
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin
Aug 9, 2011·Molecular Cancer Research : MCR·Keren CohenOsnat Ashur-Fabian
Aug 10, 2011·Journal of Cellular Physiology·Gabriele V GnoniLuisa Siculella
Sep 21, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chao WangHong-Yang Wang
Oct 14, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chen-Hsin LiaoKwang-Huei Lin
Sep 5, 2012·The Journal of Clinical Investigation·Gregory A Brent
Dec 15, 2012·Critical Reviews in Oncogenesis·Thomas N Seyfried, Leanne C Huysentruyt
Feb 28, 2013·Cancer Research·Ya-Hui HuangKwang-Huei Lin
Feb 5, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Richard CallaghanMary Bebawy
May 23, 2014·Science Signaling·Hema KalyanaramanRenate B Pilz
Nov 29, 2014·International Journal of Cancer. Journal International Du Cancer·Sheng-Ming WuKwang-Huei Lin
Jan 27, 2015·Journal of Hepatology·Yang-Hsiang LinKwang-Huei Lin

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
immunoprecipitation
ubiquitination
xenograft

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Parkinson's Disease & Autophagy (MDS)

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in Parkinson’s disease.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association
G Sebastian HönesLars C Moeller
Journal of Endocrinology, Diabetes & Obesity
Teresa L Mastracci, Carmella Evans-Molina
© 2022 Meta ULC. All rights reserved