Thyroid hormone metabolism in heart failure: iodothyronine deiodinases in focus

Current Opinion in Endocrinology, Diabetes, and Obesity
Emerson L Olivares, Denise P Carvalho

Abstract

Heart disease is the leading cause of death worldwide and no efficient treatment against this threatening condition exists. Based on their recognized regulatory action on cardiovascular system, thyroid hormones emerged as a good alternative for patients with heart disease. Although many studies have shown beneficial effects of thyroid hormone replacement in patients with heart failure, many questions are still unsolved. Thus, the purpose of this review was to discuss changes in thyroid hormone economy with special emphasis on thyroid hormone metabolism in models of heart failure. Severe illness, such as heart failure, is characterized by changes in thyroid hormone economy, characterized by decreased serum T3 and increased serum rT3, a condition called the 'low T3-syndrome'. Unlike other animal models of thyroid status derangement during systemic illness, some clinical and experimental studies have observed compensatory stimulation of the hypothalamus-pituitary-thyroid axis in patients and models of heart failure. In this context, induction of type 3 deiodinase is the main cause of decreased T3. This is uniquely reminiscent of the pathophysiology of the 'consumptive hypothyroidism', which has previously been described in patient...Continue Reading

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Citations

Aug 25, 2012·Current Heart Failure Reports·Filippos K Triposkiadis, John Skoularigis
Sep 10, 2011·Neuropharmacology·Emerson L OlivaresFábio F Rocha
Jun 4, 2020·Hormones : International Journal of Endocrinology and Metabolism·Adel Abdel-MoneimGamal Allam
Mar 9, 2019·Cardiovascular Drugs and Therapy·Catarina ValeAdelino Leite-Moreira
Oct 17, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F A C SearaE L Olivares
Feb 12, 2021·Metallomics : Integrated Biometal Science·Yanni LiBin Wu

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