PMID: 9178850May 9, 1997Paper

Thyroid hormone metabolism in the rat brain in an animal model of 'behavioral dependence' on ethanol

Neuroscience Letters
A BaumgartnerH Meinhold

Abstract

Thyroid hormone metabolism was investigated in the frontal cortex and amygdala in groups of rats either 'behaviorally dependent' on ethanol or chronically exposed to ethanol, but not 'dependent'. The activities of the 5'II deiodinase isoenzyme, which catalyzes the deiodination of thyroxine (T4) to the active metabolite triiodothyronine (T3), was elevated in the frontal cortex in both the 'behaviorally dependent' and the 'non-dependent' rats. The activities of the 5-II deiodinase isoenzyme, which catalyzes the inactivation of T3 to 3,3'-T2 was, however, selectively inhibited in the amygdalas of the rats 'behaviorally dependent' on ethanol, but normal in the 'non-dependent' rats. This suggests that increases in intracellular concentrations of T3 in the amygdala may be specifically related to reward mechanisms and the development of 'behavioral dependence' on ethanol.

Citations

Jun 6, 2000·Pharmacology, Biochemistry, and Behavior·M CorreaC M Aragon
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·M Dolores Escarabajal, Carlos M G Aragon
Feb 26, 1999·Brain Research. Molecular Brain Research·M EravciA Baumgartner
Nov 21, 2001·Drug and Alcohol Dependence·M CorreaC M Aragon
Apr 12, 2003·Drug and Alcohol Dependence·Etienne QuertemontPhilippe De Witte
Sep 16, 1999·Alcohol·Carla Sanchis-SeguraC M Aragon
Oct 1, 2009·Arhiv za higijenu rada i toksikologiju·Lucija Sarc, Metoda Lipnik-Stangelj
Oct 3, 2008·Alcoholism, Clinical and Experimental Research·Lorenzo LeggioGiovanni Addolorato
Nov 30, 2014·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Elie G AounLorenzo Leggio

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