PMID: 8971736Dec 1, 1996Paper

Thyroid hormone modulates inotropic responses, alpha-adrenoceptor density and catecholamine concentrations in the rat heart

Naunyn-Schmiedeberg's Archives of Pharmacology
J ZwavelingP A van Zwieten

Abstract

We investigated the influence of hyper- and hypothyroidism on basal parameters of isolated perfused hearts of rats. In addition the effects of different extracellular calcium concentrations ([Ca2+]o), the calcium entry promoter Bay K8644 and the alpha 1-adrenoceptor agonist methoxamine were investigated. Since alterations in alpha-adrenoceptor density could explain the increased sensitivity to methoxamine in hearts from hypothyroid rats, alpha 1-adrenoceptor density in the left ventricle was also established. Different time-schedules of exposure to hyper- and hypothyroidism were used to investigate whether the influence of chronic dysthyroid states on alpha 1-adrenoceptor density is transient and time-dependent. Simultaneously myocardial noradrenaline and adrenaline tissue concentrations were determined, since they might correlate with the observed changes. Hyperthyroidism was induced by feeding rats for 1, 4 and 8 weeks with 5 mg/kg L-thyroxine (T4)-containing rat chow. Hypothyroid rats were obtained by adding 0.05% propylthiouracil (PTU) to the drinking water during 1, 4 and 8 weeks. For the functional experiments animals were treated during 4 weeks, to mimic the clinical situation of a chronic endocrine disease. Langendorff ...Continue Reading

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Citations

Mar 19, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Wafaa A HassanAsmaa S Shahat
Sep 12, 2003·Journal of Cardiothoracic and Vascular Anesthesia·James TseHarvey R Weiss
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Feb 16, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Wafaa A HassanAsmaa S Shahat
Mar 4, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Yingheng LiuA Martin Gerdes
Mar 27, 2003·American Journal of Physiology. Endocrinology and Metabolism·Juan Manuel MorenoFélix Vargas
Jan 31, 2006·Molecular and Cellular Biochemistry·Shahrzad JalaliNasrin Mesaeli

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