Thyroid hormone modulates neuroglobin and cytoglobin in rat brain

Metabolic Brain Disease
Kelen Carneiro OliveiraGisele Giannocco

Abstract

Thyroid hormones (THs) are essential and crucial for brain development, playing a role in growth and differentiation. Two globins named neuroglobin (Ngb) and cytoglobin (Cygb) are located in the brain, and each one has different distribution and function: They seem to have similar action by providing O(2) for respiratory chain, and detoxification of reactive oxygen species (ROS) and nitric oxide (NO) protecting tissues against irreversible lesions. We aimed to investigate the influence of thyroid state in Ngb and Cygb metabolism in different brain regions and evaluate their responses in cerebellum, hippocampus and cerebral cortex (hereafter called as cortex) after supraphysiological doses at different time points of TH administration. Experiments were carried out in rats, divided in eight experimental groups Control (C), thyroidectomy (Tx), and thyroidectomy treated with jugular intravenous injection (i.v). T3 (100 μl/100 g) injection and sacrificed after 30, 60, 120 min and 6, 12 and 24 h. In cortex, we found increase in Ngb gene and protein expression in different time points compared to C group, however Cygb gene and protein expression were decreased. In hippocampus, Ngb and Cygb protein expression increased 24 h after i.v. ...Continue Reading

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Citations

Jul 20, 2017·Metabolic Brain Disease·Rodrigo Rodrigues da ConceiçãoGisele Giannocco
Jul 30, 2019·Oxidative Medicine and Cellular Longevity·Marco FiocchettiMaria Marino
Nov 22, 2016·Medical Gas Research·Luo-Kun Xie, Shao-Hua Yang
Sep 28, 2016·Frontiers in Neurology·Eliana BaezGeorge E Barreto
Jul 12, 2018·Molecular Neurobiology·Zoë P Van AckerSylvia Dewilde
Jul 20, 2019·Oxidative Medicine and Cellular Longevity·Evi LuyckxSylvia Dewilde
Feb 1, 2019·Metabolic Brain Disease·Rodrigo Rodrigues da ConceiçãoGisele Giannocco
Mar 7, 2021·Archives of Biochemistry and Biophysics·Marco FiocchettiMaria Marino
Sep 28, 2020·Seminars in Cell & Developmental Biology·Gisele GiannoccoJanaina Sena de Souza

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