PMID: 9169551Jun 1, 1997Paper

Thyroid hormone receptor genes of neotenic amphibians

Journal of Molecular Evolution
Rachid SafiV Laudet

Abstract

Since thyroid hormones play a pivotal role in amphibian metamorphosis we used PCR to amplify DNA fragments corresponding to a portion of the ligand-binding domain of the thyroid hormone receptor (TR) genes in several neotenic amphibians: the obligatory neotenic members of the family Proteidea the mudpuppy Necturus maculosus and Proteus anguinus as well as two members of the facultative neotenic Ambystoma genus: the axolotl Ambystoma mexicanum and the tiger salamander Ambystoma tigrinum. In addition, we looked for TR genes in the genome of an apode Typhlonectes compressicaudus. TR genes were found in all these species including the obligatory neotenic ones. The PCR fragments obtained encompass both the C and E domains and correspond to alpha and beta genes. Their sequences appear to be normal, suggesting that there is no acceleration of evolutionary rates in the TR genes of neotenic amphibians. This result is not surprising for Ambystomatidae, which are known to respond to T3 (3,3',5-triiodothyronine) but is not in agreement with biochemical and biological data showing that Proteidea cannot respond to thyroid hormones. Interestingly, by RT-PCR analysis we observed a high expression levels of TRalpha in gills, intestine, and musc...Continue Reading

Citations

Feb 26, 2000·Thyroid : Official Journal of the American Thyroid Association·D Forrest, B Vennström
Feb 23, 2007·Biological Reviews of the Cambridge Philosophical Society·Tiphaine Davit-BéalJean-Yves Sire
Apr 12, 2014·Science·Teri EvansMatthew Loose
Mar 27, 2010·General and Comparative Endocrinology·Pia Bagamasbad, Robert J Denver
Apr 16, 2003·Molecular Ecology·S R VossH B Shaffer
May 12, 2006·Evolution & Development·Rachid SafiVincent Laudet
Oct 30, 2013·American Journal of Medical Genetics. Part a·Ginevra Zanni, John M Opitz
Mar 31, 2005·Seminars in Cell & Developmental Biology·Keisuke NakajimaYoshio Yaoita
Nov 4, 2005·General and Comparative Endocrinology·Daniel R BuchholzYun-Bo Shi
Jan 5, 2011·Biochimica Et Biophysica Acta·Maria Sirakov, Michelina Plateroti
Jul 4, 2002·The Journal of Biological Chemistry·Wayland LimJ David Furlow
Apr 2, 2004·The Journal of Biological Chemistry·J David FurlowThomas S Scanlan
Jul 6, 2000·Insect Biochemistry and Molecular Biology·J R Tata

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