Thyroid hormone regulates expression of shaker-related potassium channel mRNA in rat heart

Biochemical and Biophysical Research Communications
A AbeY Aizawa

Abstract

Effects of thyroid hormones on cardiac function or rhythm have been known; however, the mechanism is still unclear. In the present study examined were effects of triiodethyronine (T3) on voltage-gated potassium channel gene expression in rat heart since the potassium channels were presumed to modulate cardiac functions. The mRNA expression of five voltage-gated potassium channel gene alpha subunits (Kv1.2, Kv1.4, Kv1.5, Kv2.1, and Kv4.2) in heart was examined by ribonuclease protection assay in rats which were treated with T3 or propylthyouracil (PTU). All these genes except Kv1.4 mRNA were apparently expressed in the normal rat heart ventricle. Kv1.2 mRNA expression in ventricle was markedly suppressed by T3-treatment and enhanced by PTU-treatment. Interestingly, upregulation of Kv1.4 mRNA expression and downregulation of Kv1.5 mRNA expression were concomitantly induced in the ventricle by the PTU-treatment. In addition, the downregulation of the ventricular Kv1.5 mRNA expression induced by PTU was restored by T3 replacement. No changes of Kv2.1 and Kv4.2 mRNA expression were observed in the ventricles by the T3- or PTU-treatment. In heart atrium the same findings were observed. Kv1.4 mRNA expression, which was detectable in c...Continue Reading

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Citations

Feb 11, 2012·American Journal of Physiology. Cell Physiology·Ayako MakinoWolfgang H Dillmann
Apr 4, 2009·Thyroid Research·Agata Bielecka-DabrowaMaciej Banach
Apr 17, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Takaaki ShionoYoshifusa Aizawa
May 3, 2013·PloS One·Maria Alícia Carrillo-SepúlvedaMaria Luiza M Barreto-Chaves
May 14, 2010·Journal of Molecular and Cellular Cardiology·Emiliano MedeiJosé Hamilton Matheus Nascimento
Nov 18, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·G CiniG Iervasi
Aug 27, 2009·PloS One·Anne-Elise TobinDavid J Schulz
May 17, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Ying HuWolfgang H Dillmann
Mar 24, 2017·Cell & Bioscience·Duo ZhangHao Ying
Aug 15, 2003·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Berrin CetinarslanBaki Komsuoglu
Oct 22, 2005·Endocrine Research·Hiroshi WatanabeKenichi Watanabe
Mar 17, 2021·Cardiovascular Research·Martin AguilarSvetlana Reilly

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