Thyroid hormone regulates the expression of alpha-internexin in neurons in culture

Neuroreport
D C SampsonR P Ekins

Abstract

Maternal hypothyroidism in the rat compromises alpha-internexin (alpha-IN) expression in early fetal brain. We have therefore examined whether 3,5,3'-triiodothyronine (T3) regulates alpha-IN expression in fetal brain neurons in culture. Cells expressed transcripts encoding T3 nuclear receptor isoforms in a T3-independent manner. alpha-IN protein abundance was increased in cultures treated with 0.1 and 1 nM T3 for 20 h (177 and 185% control, respectively) and in cultures treated with 1 nM T3 for 40 h (131% control). alpha-IN transcript abundance was unaffected by T3 treatment. In conclusion, T3 at a physiological level, stimulates alpha-IN protein, but not mRNA, levels in early differentiating neurons in culture. This supports the hypothesis that maternal thyroid hormone directly regulates early neuronal differentiation.

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Citations

Aug 24, 2004·Thyroid : Official Journal of the American Thyroid Association·Neslihan Başçil TütüncüSeyhan Sözay
Feb 8, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Zhenzhen ZhengHuifang Shang

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