Thyroid hormone regulation of a transcriptional coactivator in Xenopus laevis: implication for a role in postembryonic tissue remodeling

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Tosikazu AmanoYun-Bo Shi

Abstract

Thyroid hormone (TH) affects biological processes by regulating gene transcription through TH receptors (TRs). In the presence of TH, TR activates target gene transcription by recruiting one or more transcription coactivators belonging to diverse groups. Here, we demonstrate that during TH-dependent anuran metamorphosis, one such coactivator gene, the Xenopus laevis homolog of human Trip7, is up-regulated by TH. Kinetic studies suggest that Xenopus Trip7 is most likely induced indirectly by TH in a tissue-dependent manner. In the intestine, which undergoes extensive remodeling as the animal changes from being herbivorous to carnivorous, Trip7 is expressed at high levels during but not before or after metamorphosis. It is also up-regulated in other growing or remodeling tissues such as the brain and limb but not in degenerating tadpole tail skin. By using frog oocyte as a model, we show that Trip7 influences basal transcription in a chromatin structure-dependent manner but enhances the function of liganded TR regardless of the chromatin structure of the target promoter. In vitro studies indicate that Trip7 interacts directly with TR. These results suggest that during Xenopus metamorphosis, TH up-regulates, albeit indirectly, Tri...Continue Reading

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Citations

Apr 15, 2004·Molecular and Cellular Biology·Katherine L WestMichael Bustin
Dec 14, 2011·The Biochemical Journal·Gráinne BarkessKatherine L West
Jan 16, 2007·The Journal of Biological Chemistry·Bindu D PaulYun-Bo Shi
Aug 2, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Tosikazu AmanoYun-Bo Shi
Oct 28, 2004·Biochemical Society Transactions·K L West
Feb 9, 2006·Trends in Endocrinology and Metabolism : TEM·J David Furlow, Eric S Neff
May 8, 2007·Mechanisms of Development·Yukiyasu SatoYun-Bo Shi

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