Thyroid hormone signaling acts as a neurogenic switch by repressing Sox2 in the adult neural stem cell niche

Cell Stem Cell
Alejandra López-JuárezBarbara A Demeneix

Abstract

The subventricular zone (SVZ) neural stem cell niche contains mixed populations of stem cells, transit-amplifying cells, and migrating neuroblasts. Deciphering how endogenous signals, such as hormones, affect the balance between these cell types is essential for understanding the physiology of niche plasticity and homeostasis. We show that Thyroid Hormone (T(3)) and its receptor, TRα1, are directly involved in maintaining this balance. TRα1 is expressed in amplifying and migrating cells. In vivo gain- and loss-of-function experiments demonstrate first, that T(3)/TRα1 directly repress Sox2 expression, and second, that TRα1 overexpression in the niche favors the appearance of DCX+ migrating neuroblasts. Lack of TRα increases numbers of SOX2+ cells in the SVZ. Hypothyroidism increases proportions of cells in interphase. Thus, in the adult SVZ, T(3)/TRα1 together favor neural stem cell commitment and progression toward a migrating neuroblast phenotype; this transition correlates with T(3)/TRα1-dependent transcriptional repression of Sox2.

References

Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·F DoetschA Alvarez-Buylla
Feb 28, 2002·Molecular and Cellular Neurosciences·Gregory F LemkineBarbara A Demeneix
Jun 29, 2002·Molecular Endocrinology·Hajer GuissoumaBarbara A Demeneix
Jul 24, 2002·Nucleic Acids Research·Mizuho TomiokaAkihiko Okuda
Sep 2, 2003·Neuron·Victoria GrahamLarysa Pevny
Oct 1, 2003·Nature Neuroscience·Magdalena BylundJonas Muhr
Oct 30, 2004·The Journal of Gene Medicine·Zahra HassaniBarbara A Demeneix
Feb 25, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G F LemkineB A Demeneix
Mar 21, 2006·The Journal of Biological Chemistry·Satoru MiyagiAkihiko Okuda
May 19, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takaaki KuwajimaKazuaki Yoshikawa
Apr 12, 2007·Nucleic Acids Research·Zahra HassaniBarbara A Demeneix
Sep 5, 2008·Current Opinion in Endocrinology, Diabetes, and Obesity·Mary H Samuels
Sep 13, 2008·Cell Stem Cell·Masoud TavazoieFiona Doetsch
Sep 8, 2009·The International Journal of Biochemistry & Cell Biology·Larysa H Pevny, Silvia K Nicolis
Sep 10, 2009·Molecular and Cellular Endocrinology·Elsa KressMichelina Plateroti
Sep 22, 2009·Expert Opinion on Therapeutic Targets·Monica DenticeDomenico Salvatore
Nov 10, 2009·The Journal of Biological Chemistry·Victoria Moreno-ManzanoJose M Sánchez-Puelles
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Stéphanie DecherfBarbara A Demeneix
Jun 29, 2010·Behavioural Brain Research·Maximilian PilhatschGeorg Juckel
May 10, 2011·Cell Stem Cell·Erika PastranaFiona Doetsch
May 10, 2011·Cell Stem Cell·Flavio CimadamoreAlexey V Terskikh
Nov 17, 2011·Genes & Development·Maria BergslandJonas Muhr

❮ Previous
Next ❯

Citations

Jun 12, 2013·Cellular and Molecular Life Sciences : CMLS·Delphine MeffreCharbel Massaad
Mar 8, 2014·Cellular and Molecular Life Sciences : CMLS·Maria SirakovMichelina Plateroti
Mar 8, 2013·Biology of Reproduction·Tony DefalcoBlanche Capel
Apr 25, 2013·Molecular Therapy. Nucleic Acids·Sylvie RemaudGhislaine Morvan-Dubois
Aug 27, 2013·Thyroid : Official Journal of the American Thyroid Association·Ronald J KoenigUNKNOWN American Thyroid Association 2013 Annual Meeting Program Committee
Apr 1, 2014·General and Comparative Endocrinology·Stitipragyan Bhumika, Veerle M Darras
Mar 17, 2015·Journal of Neurochemistry·Richa KapoorVidita A Vaidya
Aug 15, 2012·Biochimica Et Biophysica Acta·Maria SirakovMichelina Plateroti
Mar 5, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·AlberTinka J MurkArno C Gutleb
Feb 7, 2015·Molecular Biology of the Cell·Constanza Contreras-JuradoAna Aranda
Mar 13, 2014·Cell Stem Cell·Maria M MihaylovaÖmer H Yilmaz
May 9, 2014·Frontiers in Endocrinology·Sylvie RemaudBarbara A Demeneix
Jun 15, 2016·Developmental Biology·Fernando Faunes, Juan Larraín
Aug 25, 2016·Reviews in Endocrine & Metabolic Disorders·Guihong SunYun-Bo Shi
Aug 29, 2016·Seminars in Cell & Developmental Biology·Liezhen Fu, Yun-Bo Shi
Nov 1, 2016·Molecular Neurobiology·Jae Young Lee, Steven Petratos
Jan 20, 2018·Endocrine Reviews·Vincent PrevotJerome Clasadonte
Aug 8, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Katherine L O'ShaughnessyMary E Gilbert
May 23, 2013·Endocrine Reviews·J BowersB A Demeneix
Jan 8, 2013·Médecine sciences : M/S·Sylvie RemaudBarbara A Demeneix
Jun 8, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hao ChenJoshua F Robinson
Jun 24, 2017·Cellular and Molecular Life Sciences : CMLS·Dimitrios GkikasPanagiotis K Politis
May 24, 2019·Acta Physiologica·Jean-David GothiéSylvie Remaud
Jul 6, 2019·Biologie aujourd'hui·Sylvie Remaud, Barbara Demeneix
Jul 6, 2019·Biologie aujourd'hui·Jean-Baptiste Fini, Barbara Demeneix
Mar 28, 2017·Frontiers in Neurology·Jo E Lewis, Francis J P Ebling
Jan 31, 2020·Frontiers in Endocrinology·Jayme van DalumDavid G Hazlerigg
Dec 7, 2017·Psychopharmacology·Jae-Hoon LeeJae Yong Choi

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.