Thyroid hormone signaling: Contribution to neural function, cognition, and relationship to nicotine

Neuroscience and Biobehavioral Reviews
Prescott T Leach, Thomas J Gould

Abstract

Cigarette smoking is common despite its adverse effects on health, such as cardiovascular disease and stroke. Understanding the mechanisms that contribute to the addictive properties of nicotine makes it possible to target them to prevent the initiation of smoking behavior and/or increase the chance of successful quit attempts. While highly addictive, nicotine is not generally considered to be as reinforcing as other drugs of abuse. There are likely other mechanisms at work that contribute to the addictive liability of nicotine. Nicotine modulates aspects of the endocrine system, including the thyroid, which is critical for normal cognitive functioning. It is possible that nicotine's effects on thyroid function may alter learning and memory, and this may underlie some of its addictive potential. Here, we review the literature on thyroid function and cognition, with a focus on how nicotine alters thyroid hormone signaling and the potential impact on cognition. Changes in cognition are a major symptom of nicotine addiction. Current anti-smoking therapies have modest success at best. If some of the cognitive effects of nicotine are mediated through the thyroid hormone system, then thyroid hormone agonists may be novel treatments f...Continue Reading

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Aug 16, 2016·Reviews in Endocrine & Metabolic Disorders·Patricia Joseph-BravoJean-Louis Charli
Sep 26, 2020·Scientific Reports·Rosiane Aparecida MirandaPatricia Cristina Lisboa
Dec 16, 2020·The Journal of Clinical Endocrinology and Metabolism·Ferran Moratalla-NavarroAlba Aguado

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