PMID: 6171261Mar 15, 1981Paper

Thyroid hormones and muscle protein turnover. The effect of thyroid-hormone deficiency and replacement in thryoidectomized and hypophysectomized rats

The Biochemical Journal
J G BrownD J Millward

Abstract

We have investigated the effects of thyroidectomy, hypophysectomy and 3,3',5-tri-iodothyronine replacement on protein synthesis and degradation in skeletal muscle in vivo. Thyroidectomy resulted in a decrease in the rate of protein synthesis as a result of a loss of RNA. However, RNA activity, the rate of protein synthesis per unit of RNA, was not decreased. This was the case in both young growing rats and mature nongrowing rats. Tri-iodothyronine treatment of thyroidectomized rats increased protein synthesis by increasing RNA concentration without changes in RNA activity, and this occurred even when food intake was restricted to prevent any increase in growth. The rate of protein degradation was decreased by thyroidectomy and increased by tri-iodo-thyronine replacement in both animals fed ad libitum and food-restricted animals. Hypophysectomy decreased protein synthesis by decreasing both RNA concentration and activity. these changes were reversed by tri-iodothyronine treatment even in the presence of persistent marked hypoinsulinaemia. This indicates that tri-iodothyronine can activate athe translational phase of protein synthesis in muscle in the absence of significant quantities of insulin. However, tri-iodothyronine does n...Continue Reading

Citations

Dec 1, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G R KlegerP E Ballmer
Jul 1, 1990·The Proceedings of the Nutrition Society·J M Kelly, B W McBride
Dec 1, 1984·The Journal of Experimental Zoology·D B King, J D May
Feb 1, 1988·European Journal of Clinical Investigation·W L MorrisonM J Rennie
Mar 1, 1989·Diabetes/metabolism Reviews·D J Millward, J P Rivers
Jun 1, 1983·The Proceedings of the Nutrition Society·P J Buttery
Jan 1, 1990·Nutrition Research Reviews·J M Pell, P C Bates
Apr 23, 1999·Journal of Basic and Clinical Physiology and Pharmacology·W R Miers, E J Barrett
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·V SolomonA L Goldberg
Mar 29, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Francisco CastelánMargarita Martínez-Gómez
Mar 1, 1989·Diabetes/metabolism Reviews·M A McNurlan, P J Garlick
Aug 24, 2013·Endocrine Reviews·Einav Yehuda-ShnaidmanJacob Bar-Tana
Feb 26, 2000·The Journal of Clinical Endocrinology and Metabolism·C RochonJ Grizard
Mar 11, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T A McAllisterS E Samuels
Nov 1, 1990·The American Journal of Physiology·A G KayaliV R Young
Aug 1, 1988·The American Journal of Physiology·M M JepsonD J Millward
Nov 1, 1983·The American Journal of Physiology·J S CrieK Wildenthal
Nov 21, 2000·Free Radical Biology & Medicine·J J RamseyR Weindruch
May 25, 1983·Biochimica Et Biophysica Acta·J G Brown, D J Millward
Aug 6, 1986·Biochimica Et Biophysica Acta·K HayashiV R Young
Jan 1, 1983·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·Z PocrnjicA E Haschemeyer
Aug 1, 1984·General and Comparative Endocrinology·G E MooreG Goldspink
Oct 1, 1996·Baillière's Clinical Endocrinology and Metabolism·A M Umpleby, D L Russell-Jones

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