Abstract
The article is principally intended to describe the recent evolutions in the field of research concerned with the metabolic actions of thyroid hormones and those of some of their metabolites or derivatives. Mitochondria, as a result of their functions, represent the principal objective of scientists investigating the mechanisms underlying the effects of thyroid hormones or their metabolites/derivatives. Indeed, some important recent findings concern these organelles, and in particular mitochondrial uncoupling and its modulation by effectors. Traditionally, thyroxine (T4) and tri-iodo-L-thyronine (T3) were the only thyroid hormones considered to have metabolic effects, and they alone were considered for potential as agents that might counteract some important abnormalities such as dyslipidaemias and obesity. Several observations, however, led to a reconsideration of this idea. In recent years, studies dealing with the biological activities of some natural metabolites or structural analogues of thyroid hormones have revealed abilities to ameliorate some major worldwide medical problems, such as artherosclerosis, obesity and cardiovascular diseases. Among natural metabolites, 3,5-diiodothyronine (T2) has been shown to powerfully r...Continue Reading
References
Aug 1, 1989·The Biochemical Journal·C HorstH J Seitz
Dec 31, 1997·FEBS Letters·A LanniF Goglia
Jan 10, 1998·The Journal of Physiology·M MorenoF Goglia
Apr 16, 1998·The Biochemical Journal·A LombardiF Goglia
Mar 2, 1999·FEBS Letters·A LanniF Goglia
Nov 14, 2001·Reviews in Endocrine & Metabolic Disorders·S Y Cheng
Apr 12, 2002·Journal of Neurochemistry·Yuanbin LiuDavid Schubert
Jan 29, 2003·Experimental Physiology·Joachim M WeitzelHans J Seitz
May 20, 2003·FEBS Letters·A LanniF Goglia
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fernando Goglia, Vladimir P Skulachev
Mar 17, 1962·Nature·J R TATAO LINDBERG
Jul 15, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Antonia LanniFernando Goglia
Aug 4, 2005·The Biochemical Journal·Martin D BrandEmma J Cornwall
Nov 12, 2005·Bioscience Reports·Julien MozoFrancois Criscuolo
Jun 3, 2006·Biochimica Et Biophysica Acta·H BayirV E Kagan
Jun 10, 2006·Molecular Endocrinology·Frederic FlamantJacques Samarut
Sep 2, 2006·Journal of Proteome Research·Elena SilvestriFernando Goglia
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·John P Fruehauf, Frank L Meyskens
Apr 3, 2007·The Journal of Endocrinology·Cássio M VillicevCecília H A Gouveia
Jul 5, 2007·Journal of Proteome Research·Elena SilvestriMaria Moreno
Feb 19, 2008·Thyroid : Official Journal of the American Thyroid Association·Maria MorenoFernando Goglia
Apr 1, 2008·Experimental Biology and Medicine·Elena GrasselliLaura Vergani
Apr 25, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Andrea PerraAmedeo Columbano
Apr 2, 2009·Nature Reviews. Drug Discovery·John D Baxter, Paul Webb
May 26, 2009·Journal of Hepatology·Maria Pina MollicaFernando Goglia
Jul 15, 2009·Endocrine·Pierre FlandinMaria Jimenez
Jul 25, 2009·BioFactors·Federica CioffiAssunta Lombardi
Sep 3, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Einav Yehuda-ShnaidmanJacob Bar-Tana
Nov 3, 2009·Biochimica Et Biophysica Acta·Roberto MangiulloGabriele V Gnoni
Jan 7, 2010·Endocrine Reviews·Sheue-Yann ChengPaul J Davis
Mar 12, 2010·The New England Journal of Medicine·Paul W LadensonBo Angelin
Apr 3, 2010·The Journal of Endocrinology·P VendittiS Di Meo
Citations
Jun 12, 2012·The Journal of Clinical Investigation·Rohit Anthony SinhaPaul M Yen
Jan 12, 2013·PloS One·Alessandro CavalloAntonio Gnoni
Jul 25, 2013·International Journal of Molecular Sciences·Pieter de LangeAntonia Lanni
Dec 24, 2013·World Journal of Gastroenterology : WJG·Yue-Ye HuangShen Qu
Dec 29, 2013·Toxicology Letters·G A MontoyaB van Ravenzwaay
Jun 27, 2014·Thyroid : Official Journal of the American Thyroid Association·Ina LehmphulZida Wu
Oct 6, 2015·Expert Review of Clinical Pharmacology·Sherifa Ahmed Hamed
Jul 21, 2015·International Journal of Molecular Sciences·Janina A VaitkusFrancesco S Celi
Jul 30, 2011·Domestic Animal Endocrinology·A SechmanA Hrabia
Jun 15, 2011·Molecular and Cellular Endocrinology·P VendittiS Di Meo
Mar 8, 2014·General and Comparative Endocrinology·Aurea OrozcoCarlota García-G
Mar 18, 2015·Diabetology & Metabolic Syndrome·José de Jesús Garduño-GarciaHugo Mendieta-Zerón
Feb 19, 2013·Biochimica Et Biophysica Acta·Guoguo ShangHui Li
Jun 19, 2013·Molecular and Cellular Endocrinology·Federica CioffiFernando Goglia
Mar 5, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·AlberTinka J MurkArno C Gutleb
Sep 20, 2011·Diabetes·Pieter de LangeAntonia Lanni
Jun 29, 2016·Endocrine Journal·Ronny LesmanaNoriyuki Koibuchi
Nov 18, 2016·Journal of Bioenergetics and Biomembranes·Alessandro CavalloAntonio Gnoni
Apr 1, 2017·International Journal of Molecular Sciences·Fabrizio DamianoLuisa Siculella
Feb 24, 2018·Nature Reviews. Endocrinology·Rohit A SinhaPaul M Yen
Sep 13, 2014·European Journal of Endocrinology·Ferruccio SantiniBernadette Biondi
Jan 18, 2014·Endocrine Reviews·Bernadette Biondi, Leonard Wartofsky
Nov 17, 2012·Nature Reviews. Genetics·Majesta O'BlenessJames M Sikela
Mar 29, 2014·World Journal of Hepatology·Maria CoppolaFernando Goglia
Dec 20, 2014·Endocrinology·Arturo Hernandez
Jun 28, 2018·Science Signaling·Brijesh K SinghPaul M Yen
Mar 21, 2019·Cells·Rosalba SeneseAntonia Lanni
Aug 8, 2019·Thyroid : Official Journal of the American Thyroid Association·Rohit A SinhaPaul M Yen
Apr 27, 2019·Frontiers in Endocrinology·Federica CioffiAntonia Lanni
Aug 23, 2020·International Journal of Molecular Sciences·Daniela Maria TanaseMariana Floria
Jul 9, 2020·Animals : an Open Access Journal From MDPI·Roberta ImperatoreMarina Paolucci
Oct 17, 2018·European Journal of Clinical Nutrition·Anja Bosy-WestphalManfred J Müller
Sep 16, 2021·Hormone Molecular Biology and Clinical Investigation·Niranjan GopalAshok Kumar Ahirwar