Thyroid hormones regulate the onset of osmotic activity of rat liver mitochondria after birth

Endocrinology
A AlmeidaJ M Medina

Abstract

The effect of thyroid hormone deprivation on the osmotic activity of liver mitochondria from early newborn rats was studied. Experimentally induced hypothyroidism prevented the increase in the osmotic activity of mitochondria observed immediately after birth. Osmotic activity was restored by T4 and T3 treatment to hypothyroid newborns but not when this treatment was supplemented with cycloheximide. Under the same circumstances, streptomycin had no effect. Hypothyroidism abolished the change in the slope of the osmotic curve (plot of inverse absorbance of mitochondrial suspensions incubated in sucrose solutions vs. inverse sucrose concentration) observed in mitochondria from euthyroid newborns at 110-120 mOsm sucrose, suggesting that hypothyroidism prevents the formation of tight physical connections between mitochondrial outer and inner membranes. Thyroid hormone deprivation increased the passive permeability of the mitochondrial inner membrane to protons, resulting in a decreased respiratory control ratio. Hypothyroidism prevented the sharp decrease in the affinity of mitochondria for ATP observed in euthyroid newborns immediately after birth. These results corroborate our previous suggestion (Endocrinology, 1995, 136:4448) th...Continue Reading

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Citations

Feb 4, 2005·Birth Defects Research. Part A, Clinical and Molecular Teratology·Yajun XuYong Li
Apr 1, 2005·American Journal of Physiology. Cell Physiology·Roberto JustoMagdalena Gianotti
Jan 21, 2006·The Journal of Nutrition·Tracy StitesRobert B Rucker

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