Thyroid hypofunction in Down's syndrome: is it related to oxidative stress?

Biological Trace Element Research
O J KanavinG S Birketvedt

Abstract

Oxidative stress affecting the thyroxin biosynthesis might explain the proneness of patients with Down's syndrome (DS) (trisomia 21) to develop hypothyroidism. Thyroideal cells are exposed to endogenous H2O2 that acts as a cofactor for the iodination of thyroxin precursors. The gland has high levels of selenium-containing proteins, including peroxide-detoxicating enzyme proteins. The object of the present study was to explore the hypothesis of a role of an imbalance between toxic oxygen production and protective metalloenzymes during the development of thyroid hypofunction in DS patients. We analyzed serum levels of thyroid hormones and trace metals in 38 institutionalized adults with DS, using mentally retarded subjects matched for age, sex, and behavioral function as controls. The DS patients had significantly lower mean values of free thyroxin (fT4) and increased TSH (thyroid stimulating hormone), as compared to the controls. They had lower serum selenium than the controls. A positive correlation was observed between serum concentrations of fT4 and selenium in the DS patients (r = 0.393, p < 0.05). No significant differences were found between the fT4 or the TSH concentrations in the patients with and without circulating ant...Continue Reading

Citations

May 27, 2009·Biological Trace Element Research·Adriana S LimaSilvia F Cozzolino
Oct 6, 2007·Biological Trace Element Research·Raynério Costa MarquesDilina do Nascimento Marreiro
Dec 4, 2008·Biological Trace Element Research·Dilina do Nascimento MarreiroFrancisco Erasmo Oliveira
Jul 21, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ibtissem Ben AmaraNajiba Zeghal
Nov 21, 2007·Pediatric Neurology·Michael V MilesStephanie L Hotze
Jan 4, 2012·Acta Paediatrica·Hasan OnalZerrin Onal
Dec 25, 2004·Medical Hypotheses·R Thiel, S W Fowkes
Sep 12, 2015·The Indian Journal of Medical Research·Carlos Campos, Ángela Casado
Sep 18, 2007·Research in Developmental Disabilities·Eli CarmeliJoav Merrick
Nov 14, 2017·American Journal of Medical Genetics. Part a·George T CaponeUNKNOWN Down Syndrome Medical Interest Group DSMIG-USA Adult Health Care Workgroup
May 8, 2003·Journal of the American Academy of Dermatology·Julia AiWarren R Heymann

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