Thyroid low-grade B-cell lymphoma (MALT type) with extreme plasmacytic differentiation: report of a case diagnosed by fine-needle aspiration and flow cytometric study

Diagnostic Cytopathology
Yusef M Al-MarzooqSoad H Al-Omran

Abstract

We describe a case of thyroid marginal-zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) with extreme plasmacytic differentiation in an 80-year-old woman who had presented with a rapidly growing thyroid swelling. The diagnosis was initially suspected on fine-needle aspiration (FNA) and subsequently confirmed by flow cytometric analysis of the aspirated material. The smears revealed features of Hashimoto's thyroiditis admixed with large numbers of atypical large plasmacytoid lymphoid cells accompanied by variable numbers of small lymphocytes and mature plasma cells. The differential diagnosis of a predominantly plasmacytic smears on FNA of the thyroid is discussed herein, with emphasis on the role of immunophenotypic studies to exclude or confirm the diagnosis of lymphoma.

References

Sep 1, 1991·The American Journal of Surgical Pathology·P G IsaacsonL X Pan
Jan 1, 1991·Diagnostic Cytopathology·R E DetweilerN Ordóñez
Jun 1, 1990·Histopathology·P G Isaacson
Jul 1, 1986·Cancer·K AozasaK Kuma
Aug 1, 1985·Human Pathology·R YappF W Karrer
Jul 1, 1984·Histopathology·P G IsaacsonS G Subbuswamy
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·C S KovacsJ Ginsberg
Feb 1, 1996·Pathology, Research and Practice·Y MizukamiT Ishizaki
Jan 1, 1997·Current Topics in Pathology. Ergebnisse Der Pathologie·P G Isaacson
Apr 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C ThieblemontB Coiffier
Jan 23, 1999·American Journal of Clinical Pathology·J W HussongG Frizzera
May 9, 2000·The American Journal of Surgical Pathology·G A DerringerS L Abbondanzo
Aug 8, 2001·Cytopathology : Official Journal of the British Society for Clinical Cytology·G SangalliL Colombo

❮ Previous
Next ❯

Citations

May 10, 2012·Thyroid : Official Journal of the American Thyroid Association·Vicky ChengChristian Nasr
Mar 15, 2005·Clinical Nuclear Medicine·Veronica SolisRichard P Spencer
Jan 11, 2007·American Journal of Clinical Pathology·Adam C SeegmillerNitin J Karandikar
Feb 22, 2011·Cytometry. Part B, Clinical Cytometry·Howard J MeyersonFelix Olobatuyi
May 24, 2012·Diagnostic Cytopathology·Rachel C Ochs, Adam Bagg
Nov 29, 2014·Cytometry. Part B, Clinical Cytometry·Alessandra StacchiniDomenico Novero
Feb 4, 2019·Cytopathology : Official Journal of the British Society for Clinical Cytology·Debasis GochhaitThara Keloth
Feb 20, 2020·European Thyroid Journal·Evangelos KarvounisEva Kassi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.