Thyroid microcarcinoma: prevalence, prognosis, and management.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
R AremSteven I Sherman

Abstract

To review the usual course of thyroid microcarcinoma (TMC) and the associated prognosis and treatment of affected patients. We discuss predisposing factors in the formation of TMC and the modulation of its behavior, diagnostic evaluation, and management options. TMC, generally defined as a well-differentiated thyroid cancer less than or equal to 15 mm in diameter, has an estimated prevalence (based on autopsy studies) of about 5 to 10%. Studies, however, have shown that most of these cancers are smaller than 5 mm in diameter. The high prevalence of TMC in the general population contrasts with the rarity of thyroid cancers of greater size, which constitute less than 1% of malignant neoplasms in the United States. The frequent detection of TMC as a result of routine imaging of the neck for unrelated reasons and as a incidental finding in surgical specimens has raised a question about whether the management of TMC should differ from that for thyroid cancer of appreciable size. The uncertainty about optimal management of TMC is attributable to the small number of long-term follow-up studies as well as the common observation that patients usually have an excellent prognosis. Although in most patients harboring a TMC the cancer remai...Continue Reading

References

May 1, 1979·Cancer·M A Sobrinho-SimôesV Gonçalves
Aug 1, 1979·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D P ByarM van Glabbeke
Sep 1, 1975·Cancer·F H Fukunaga, R Yatani
Jul 1, 1992·Japanese Journal of Cancer Research : Gann·W WajjwalkuM Takahashi
Jul 1, 1992·World Journal of Surgery·K KumaM Sugawara
Apr 1, 1990·The Journal of Clinical Endocrinology and Metabolism·A BelfioreR Vigneri
Aug 1, 1990·The Journal of Clinical Endocrinology and Metabolism·L J DeGrootF H Straus
Jul 1, 1988·American Journal of Clinical Pathology·W LangL Bauer
Dec 1, 1987·Cancer·A L VickeryA M Walker
Sep 15, 1984·Cancer·S M StrateJ H Childers
Apr 15, 1984·Cancer·L Bondeson, O Ljungberg
May 1, 1983·Cancer·M C SambadeM A Sobrinho-Simões
Mar 1, 1982·AJR. American Journal of Roentgenology·B A Carroll
Feb 1, 1994·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·J N BrunetonM Y Mourou
Nov 1, 1994·The American Journal of Medicine·E L Mazzaferri, S M Jhiang
Jan 1, 1994·World Journal of Surgery·L J DeGrootM S Shukla
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·W LangstegerO Eber
Oct 1, 1993·The British Journal of Surgery·T TerzioğluR Tanakol
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B SalvadoriF Cusumano
Nov 1, 1993·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·K ShimamotoN Makino
Aug 1, 1993·The Laryngoscope·A P SclafaniH Cho
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M A SattaA Picciocchi
Feb 1, 1996·Archives of Surgery·S NoguchiH Kawamoto
Sep 1, 1996·The Journal of Clinical Endocrinology and Metabolism·S L SuggS L Asa
Jun 1, 1997·Cancer·B D'AvanzoR Zleglar
Mar 10, 1998·Thyroid : Official Journal of the American Thyroid Association·D DaneseA Pontecorvi
Jun 12, 1998·Thyroid : Official Journal of the American Thyroid Association·R M TuttleH B Burch
Sep 1, 1952·American Journal of Clinical Pathology·J B HAZARD, N KAUFMAN

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Citations

Aug 4, 2001·Thyroid : Official Journal of the American Thyroid Association·Z W Baloch, V A LiVolsi
Dec 1, 2007·Thyroid : Official Journal of the American Thyroid Association·Kalliopi Pazaitou-PanayiotouFurio Pacini
Oct 24, 2012·Journal of Thyroid Research·Beatriz MantinanRicardo V Garcia-Mayor
Sep 26, 2013·Thyroid : Official Journal of the American Thyroid Association·Lorraine R ReitzelErich M Sturgis
Jul 31, 2007·Future Oncology·Andrew J VardanianMichael W Yeh
Aug 7, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Furio Pacini
May 29, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Furio Pacini
Jan 16, 2002·American Journal of Clinical Pathology·Zubair W Baloch, Virginia A Livolsi
Apr 2, 2016·European Journal of Endocrinology·Maria Annateresa ProvenzalePaolo Vitti
Sep 26, 2007·Expert Review of Anticancer Therapy·Adonis T RamirezFausto Chiesa
Jun 21, 2002·International Journal of Surgical Pathology·Grace C H YangZubair W Baloch
Dec 22, 2011·Yonsei Medical Journal·Ernest L Mazzaferri
Aug 8, 2018·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ayaka J IwataMichael C Singer
Jan 29, 2019·Applied Immunohistochemistry & Molecular Morphology : AIMM·Xiaoqi LinJan F Silverman
Jul 15, 2005·Expert Review of Molecular Diagnostics·Zubair W Baloch, Virginia A LiVolsi
May 4, 2006·Advances in Anatomic Pathology·Zubair W Baloch, Virginia A LiVolsi
Dec 4, 2015·Current Opinion in Oncology·Ahmad AlhashemiAnna M Sawka
Mar 16, 2007·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Marco CapezzoneRocco Bruno

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