Thyroid nodules on chest CT of patients with tuberous sclerosis complex

American Journal of Medical Genetics. Part a
Maria AuladellE A Thiele

Abstract

A few cases of thyroid disease have been reported in tuberous sclerosis complex (TSC); however, studies on prevalence and characterization of lesions have not been done. Patients with TSC are routinely screened using chest CT for assessment of lung disease. Incidental thyroid findings on chest CT have been reported in large studies of the general population. The purpose of this study is to evaluate the frequency and type of thyroid anomalies in a cohort of TSC patients. We performed a retrospective review of 93 patients with a definite diagnosis of TSC, who had a chest CT. Images of the thyroid gland and final radiological report were reviewed. Reports of additional thyroid studies performed in some patients were also reviewed. Thyroid abnormalities were present in 19 of 93 (20.4%) patients. They consisted mainly of hypodense lesions categorized as nodules. Multiple nodules were found in 10 patients (52.6%). There was one papillary carcinoma. Thyroid gland lesions may be part of the clinical spectrum of TSC. They are usually asymptomatic. As some cases of thyroid carcinoma have been described in TSC, ultrasound exams are recommended, given that CT is not the gold standard technique for thyroid evaluation.

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Citations

Aug 30, 2018·American Journal of Medical Genetics. Part C, Seminars in Medical Genetics·Susana Boronat, Ignasi Barber
Aug 17, 2021·Pediatric Neurology·Hope NorthrupUNKNOWN International Tuberous Sclerosis Complex Consensus Group

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