PMID: 15350189Sep 8, 2004Paper

Thyroid papillary carcinoma: preliminary evidence for a germ-line single nucleotide polymorphism in the Fas gene

The Journal of Endocrinology
F BasoloA Toniolo

Abstract

The expression of Fas in thyroid tumours and Graves' disease was analysed by mRNA transcript expression. As compared with unaffected thyroid tissue, Fas expression was enhanced in Graves' disease, adenomas, and papillary and follicular carcinomas. This pattern was also reflected in immunohistochemical studies. The PCR single-strand conformational polymorphism (SSCP) method and DNA sequencing were used to analyse Fas exons 1-9. The study was carried out on five different histotypes of thyroid tumours (n=93) and tissue from Graves' disease patients. As compared with a group of healthy blood donors (n=64), a significant association (P=0.006) emerged between papillary thyroid carcinoma and a silent single nucleotide polymorphism (SNP, 988C-->T) in exon 7 of the Fas gene. Other forms of thyroid pathology were not associated with the above polymorphism. Patients with neoplasia showed the same SNP in tumour tissue, in the unaffected contralateral thyroid lobe, and in peripheral blood cells. Thus, the 988C-->T polymorphism appeared to be of germ-line origin.

Citations

May 17, 2005·Gynecologic Oncology·Masatsugu UedaMinoru Ueki
Dec 20, 2007·Journal of Pediatric Hematology/oncology·Nadezhda V KoshkinaErich M Sturgis
Jan 22, 2010·Indian Journal of Pathology & Microbiology·Urmila N KhadilkarKrishna Prasad
Jun 30, 2007·Journal of Endocrinological Investigation·M ErdoganA G Ozgen
Mar 14, 2014·Endocrine-related Cancer·Shahnawaz ImamJuan Carlos Jaume
Jul 4, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Juliana J OhDennis J Slamon
Nov 12, 2014·International Journal of Endocrinology·Yulu GuYawen Liu
Mar 14, 2007·Journal of Vascular Surgery·Jian ZhangJens R Allenberg
Feb 3, 2009·The Lancet Oncology·Elisabeth AdjadjFlorent de Vathaire
Jan 16, 2007·Arquivos brasileiros de endocrinologia e metabologia·Luciane MartinsEdna Teruko Kimura

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