Thyroid peroxidase autoantibody epitopic 'fingerprints' in juvenile Hashimoto's thyroiditis: evidence for conservation over time and in families

Clinical and Experimental Immunology
J C JaumeB Rapoport

Abstract

In Hashimoto's thyroiditis, the humoral component is manifest by autoantibodies to thyroid peroxidase (TPO). Epitopic 'fingerprinting' of polyclonal serum TPO autoantibodies has been facilitated by the molecular cloning and expression as Fab of a repertoire of human TPO autoantibody genes. To investigate whether TPO autoantibody fingerprints are (i) stable over long periods of time (approximately 15 years), and (ii) inherited, we studied a cohort of nine patients with juvenile Hashimoto's thyroiditis and 21 first degree relatives of four of these patients. Fingerprints were determined by competition between four selected FAB and serum autoantibodies for binding to 125I-TPO. Regardless of titre, the TPO epitopic profile was stable in 10/12 individuals whose TPO autoantibody levels were sufficient for analysis on two or three occasions over 12-15 years. Although the TPO epitopic fingerprint profiles in two families raised the possibility of inheritance, overall the data from all four families did not reveal an obvious pattern of genetic control. In no family was the TPO epitopic fingerprint associated with HLA A, B or DR. In conclusion, TPO autoantibody epitopic fingerprints are frequently conserved over many years. Studies on ad...Continue Reading

Citations

Sep 29, 2005·Thyroid : Official Journal of the American Thyroid Association·O E OkosiemeJ H Lazarus
Mar 5, 1998·Clinical and Experimental Immunology·J GuoS M McLachlan
Apr 14, 2005·Best Practice & Research. Clinical Endocrinology & Metabolism·Mark F Prummel, Wilmar M Wiersinga
Mar 28, 2008·Clinical Endocrinology·Sandra M McLachlan, Basil Rapoport
Apr 26, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nancy S LongoPeter E Lipsky
Jan 13, 2018·Frontiers in Immunology·Sandra M McLachlan, Basil Rapoport
Jun 1, 1997·Thyroid : Official Journal of the American Thyroid Association·R S McIntosh, A P Weetman
Dec 29, 2000·International Reviews of Immunology·S M McLachlan, B Rapoport
Dec 26, 2018·International Journal of Endocrinology and Metabolism·Maryam S DaneshpourFereidoun Azizi
Apr 14, 2005·Endocrine Reviews·Sandra M McLachlanBasil Rapoport

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