PMID: 18406755Sep 1, 1996Paper

Thyroid-specific enhancer-binding protein Role in thyroid function and organogenesis

Trends in Endocrinology and Metabolism : TEM
Shioko Kimura

Abstract

Thyroid-specific enhancer-binding protein (T/EBP), also known as thyroid-specific transcription factor-1 (TTF-1), is a trans-activating transcription factor known to be involved in the tissue-specific expression of genes encoding thyroglobulin (TG), thyroid peroxidase (TPO), and thyrotropin receptor (TSHR) in the thyroid, and surfactant proteins A, B, and C, and Clara cell secretory protein in the lung. T/EBP is a homeodomain-containing DNA-binding protein found in the thyroid, lung epithelium, and specific areas of the forebrain during early embryogenesis. A mutant mouse lacking T/EBP expression was recently generated that is missing the thyroid, lung, ventral forebrain, and pituitary. These results clearly establish that T/EBP functions not only as a trans-activating factor to regulate expression of genes in the thyroid and lung, but also is required for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.

References

Oct 1, 1992·Molecular and Cellular Endocrinology·C Christophe-HobertusD Christophe
Feb 1, 1992·European Journal of Biochemistry·M J AbramowiczD Christophe
Jan 1, 1991·Genes & Development·V E AvvedimentoM E Gottesman
Jan 1, 1989·Advances in Experimental Medicine and Biology·L D KohnC M Rotella
Jan 1, 1995·Vitamins and Hormones·L D KohnM Saji
May 5, 1995·The Journal of Biological Chemistry·T EndoT Onaya
Aug 2, 1994·Biochimica Et Biophysica Acta·G Damante, R Di Lauro

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Citations

Jun 18, 2016·The Journal of Biological Chemistry·Guillaume HolzerVincent Laudet
Nov 6, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jessica WesterlundMikael Nilsson
Mar 20, 2019·Nature Reviews. Endocrinology·Cintia E CitterioPeter Arvan
Jun 27, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jia LiuYutong Zhao
Jan 24, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Junguee LeeMinho Shong
Jun 1, 1997·Endocrine Reviews·K L Parker, B P Schimmer
Jul 3, 2013·Current Opinion in Neurology·Felix Gövert, Susanne A Schneider
Mar 3, 2010·American Journal of Respiratory and Critical Care Medicine·Yusuke TakahashiEiji Ikeda
Jul 23, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Moonsik KimHyo Sup Shim

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