Thyroid status and mortality in nonagenarians from long-lived families and the general population

Aging
Nicolien A van VlietDiana van Heemst

Abstract

The relationship between thyroid status and longevity has been investigated extensively. However, data on thyroid status and survival in old age is scarce. In this study we investigated associations of different parameters of thyroid status with mortality in nonagenarians, and whether these associations were different in nonagenarians from long-lived families than in nonagenarians from the general population. In total, 805 nonagenarians from the Leiden Longevity Study and 259 nonagenarians from the Leiden 85-plus Study were followed up to collect mortality data. At baseline, levels of thyrotropin (TSH), free thyroxine (fT4) and free triiodothyronine (fT3) were measured. In nonagenarians from long-lived families and from the general population, associations between thyroid parameters and mortality were similar. We found no interaction between study population and parameters of thyroid status on mortality (P-values>0.70). The results from both studies were combined to derive generalizable associations. Hazard ratios (HRs) for the highest compared to lowest tertiles were determined, resulting in TSH HR 0.91 (P=0.25), fT4 HR 1.22 (P=0.02), fT3 HR 0.74 (P=1.31e-4), and fT3/fT4 HR 0.66 (P=5.64e-7). In conclusion, higher fT3/fT4 ratio...Continue Reading

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Citations

Aug 31, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Rita OstanGiovanni Vitale
Sep 5, 2019·Endocrine·Leonidas H Duntas, Paul Michael Yen
Sep 24, 2020·Journal of the Endocrine Society·Ana ZutinicDiana van Heemst
Oct 22, 2019·Current Opinion in Endocrine and Metabolic Research·Jennifer S Mammen
Apr 2, 2021·Frontiers in Endocrinology·Grigoris EffraimidisUlla Feldt-Rasmussen
Nov 25, 2021·European Geriatric Medicine·Aline S da S CorreiaPatricia F S Teixeira

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Software Mentioned

GraphPad Prism
Stata Data analysis and Statistical Software
Statistical Package for the Social Sciences ( SPSS )
R

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