Thyroid Stimulating Hormone and Bone Mineral Density: Evidence From a Two-Sample Mendelian Randomization Study and a Candidate Gene Association Study

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Nicolien A van VlietDiana van Heemst

Abstract

With population aging, prevalence of low bone mineral density (BMD) and associated fracture risk are increased. To determine whether low circulating thyroid stimulating hormone (TSH) levels within the normal range are causally related to BMD, we conducted a two-sample Mendelian randomization (MR) study. Furthermore, we tested whether common genetic variants in the TSH receptor (TSHR) gene and genetic variants influencing expression of TSHR (expression quantitative trait loci [eQTLs]) are associated with BMD. For both analyses, we used summary-level data of genomewide association studies (GWASs) investigating BMD of the femoral neck (n = 32,735) and the lumbar spine (n = 28,498) in cohorts of European ancestry from the Genetic Factors of Osteoporosis (GEFOS) Consortium. For the MR study, we selected 20 genetic variants that were previously identified for circulating TSH levels in a GWAS meta-analysis (n = 26,420). All independent genetic instruments for TSH were combined in analyses for both femoral neck and lumbar spine BMD. In these studies, we found no evidence that a genetically determined 1-standard deviation (SD) decrease in circulating TSH concentration was associated with femoral neck BMD (0.003 SD decrease in BMD per SD...Continue Reading

References

Mar 27, 1993·Lancet·D W Dempster, R Lindsay
Dec 16, 1998·Thyroid : Official Journal of the American Thyroid Association·M InoueT Onaya
Aug 22, 2003·Thyroid : Official Journal of the American Thyroid Association·Peter Vestergaard, Leif Mosekilde
Oct 22, 2003·Cell·Etsuko AbeMone Zaidi
Dec 4, 2003·Thyroid : Official Journal of the American Thyroid Association·Stig AndersenPeter Laurberg
Feb 13, 2004·Calcified Tissue International·J A TsaiO Torring
Mar 5, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Gherardo MazziottiCarlo Carella
Aug 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hidenori HaseEtsuko Abe
Mar 14, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T Kuber SampathSlobodan Vukicevic
Sep 22, 2007·Statistics in Medicine·Debbie A LawlorGeorge Davey Smith
Mar 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·Li SunMone Zaidi
Apr 11, 2008·Thyroid : Official Journal of the American Thyroid Association·Giuseppe MartiniFurio Pacini
Jul 1, 2008·Bone·J H Duncan Bassett, Graham R Williams
Jun 24, 2009·Journal of Bone and Mineral Metabolism·Helen KargaPanayotis Papaioannou
May 27, 2010·The Journal of Biological Chemistry·Liza J Raggatt, Nicola C Partridge
Sep 4, 2010·International Journal of Epidemiology·Brandon L PierceTyler J Vanderweele
Sep 14, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ramkumarie BaliramTerry F Davies
May 23, 2013·Endocrine Reviews·J BowersB A Demeneix
Oct 26, 2013·International Journal of Epidemiology·Marie-Jo A BrionPeter M Visscher
Jan 22, 2014·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·I Dumic-CuleS Vukicevic
Mar 10, 2015·Endocrine Reviews·Marco MediciRobin P Peeters
Mar 17, 2015·European Journal of Epidemiology·Stephen BurgessUNKNOWN EPIC- InterAct Consortium
Mar 31, 2015·Journal of Cellular Physiology·Elizabeth CurtisElaine Dennison
May 27, 2015·JAMA : the Journal of the American Medical Association·Manuel R BlumUNKNOWN Thyroid Studies Collaboration
Jun 8, 2015·International Journal of Epidemiology·Jack BowdenStephen Burgess
Aug 13, 2015·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·E TsourdiA Hannemann
Feb 11, 2016·Endocrine Reviews·J H Duncan Bassett, Graham R Williams
Mar 11, 2016·The American Journal of Clinical Nutrition·Philip C HaycockGeorge Davey Smith
Mar 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Maxime M BosRaymond Noordam
May 10, 2017·The Journal of Clinical Endocrinology and Metabolism·Carole E AubertUNKNOWN Thyroid Studies Collaboration
Oct 17, 2017·Journal of Internal Medicine·D SegnaUNKNOWN Thyroid Studies Collaboration
Nov 21, 2017·PloS One·Rudolf HoermannJohannes Wolfgang Christian Dietrich

❮ Previous
Next ❯

Citations

Dec 6, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Yoonjeong ChoiSun Ha Jee
Apr 10, 2020·The Journal of Clinical Endocrinology and Metabolism·Aleksander KuśMarco Medici
Sep 9, 2020·Current Osteoporosis Reports·M A ChristouD Karasik
Jan 23, 2020·Medicina·Jan Calissendorff, Henrik Falhammar
Jul 23, 2020·Journal of Endocrinological Investigation·M CelliniG Mazziotti
Dec 12, 2019·Frontiers in Endocrinology·Jie ZhengJonathan H Tobias
Jan 9, 2020·Thyroid : Official Journal of the American Thyroid Association·Christina EllervikDaniel I Chasman
Oct 16, 2018·Bone·Susanna C LarssonStephen Burgess
Jul 31, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Alexander Kalinkovich, Gregory Livshits
Jul 3, 2021·Thyroid : Official Journal of the American Thyroid Association·Christina EllervikAlisa D Kjaergaard
Jul 29, 2021·The Journal of Clinical Endocrinology and Metabolism·Se-Min KimMone Zaidi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Genetics & Epigenetics of Aging

Dozens of genes are implicated in lifespan, and epigenetic changes during aging affect cell function. This feed focuses on the genetics and epigenetics of aging.

Related Papers

The Journal of Clinical Endocrinology and Metabolism
Maxime M BosRaymond Noordam
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Susanna C LarssonKarl Michaëlsson
© 2021 Meta ULC. All rights reserved