Thyroid-Stimulating Hormone-Secreting Pituitary Adenomas : Single Institutional Experience of 14 Consecutive Cases

Journal of Korean Neurosurgical Society
Joonho ByunChang Jin Kim

Abstract

Thyroid-stimulating hormone (TSH)-secreting pituitary adenoma (PA) is an extremely rare functioning form of PA that accounts for 0.7-2% of all such cases. The previously reported outcomes of the surgical removal of TSH-PA are poor. Owing to its extremely low incidence, most available reports on TSH-PA are case reports or small case series. Thus, we investigated the clinical and endocrinological outcomes of surgically treated TSH-PA through our institutional series. We retrospectively reviewed 14 consecutive cases of surgically treated TSH-PA, focusing on the clinical, radiological, surgical, and endocrinological data. There were seven male (50%) and seven female (50%) patients. The mean age was 42.5 years (range, 19-63). The mean tumor size was 16.6 mm (range, 4-30). Optic chiasm compression was noted in six patients (42.9%), and no patient showed cavernous sinus invasion. Thirteen of 14 patients (92.8%) underwent transnasal transsphenoidal approach (TSA), and one patient underwent TSA followed by transcranial approach for residual tumor removal. Thirteen of 14 patients (92.8%) showed endocrinological remission; all patients who experienced remission showed subnormal levels of TSH (<0.4 μU/mL) on postoperative day 2. Recurrence...Continue Reading

References

Aug 10, 2000·Journal of Neurosurgery·N SannoR Y Osamura
Apr 5, 2003·Pituitary·Paolo Beck-Peccoz, Luca Persani
Jan 9, 2013·The Journal of Clinical Endocrinology and Metabolism·Lisa ÓnnestamHelena Filipsson Nyström
Aug 3, 2014·European Journal of Endocrinology·Axel TjörnstrandHelena Filipsson Nyström
Jun 23, 2016·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Giuseppe MinnitiRiccardo Maurizi Enrici
Oct 13, 2016·Radiation Oncology·Giuseppe MinnitiMaximillian Niyazi
Feb 17, 2017·Acta neurochirurgica·Roman RotermundJörg Flitsch
May 5, 2017·Health Services Insights·Marcia Rashelle Palace
Jun 2, 2017·European Journal of Endocrinology·Axel Tjörnstrand, Helena Filipsson Nyström

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