PMID: 6170289Jun 1, 1981Paper

Thyroid stimulating immunoglobulin in Graves' disease

Australian and New Zealand Journal of Medicine
B M Luttrell, I B Hales

Abstract

There is excellent presumptive evidence that an IgG plays an aetiological role in the development of hyperthyroidism in Graves' disease but available methods for detecting thyroid stimulating immunoglobulins (TSI) are still far from satisfactory. They show considerable variation in specificity, sensitivity and precision, and comparison of the experimental data, obtained with these various methods, is difficult. A need exists for an in vitro TSI assay which is based upon the propensity of IgG molecules to stimulate the thyroid gland. Because a complex chain of biochemical events is involved, including binding to IgG to the cell membrane receptor, release of cyclic AMP, organification of iodide, hydrolysis of iodoproteins and secretion of thyroid hormones, it is not yet clear which step should be monitored to obtain the best index of thyroid stimulating activity. Although TSI and related assays appear to be of limited value in the primary diagnosis of Graves' disease, they offer some assistance to the clinician in the following situations: 1. Prediction of relapse in Graves' disease patients who have been rendered euthyroid with antithyroid drugs. 2. Identification of patients with ophthalmic Graves' disease. 3. Prediction of neo...Continue Reading

References

May 1, 1978·The Journal of Clinical Endocrinology and Metabolism·J O'DonnellR Volpé
Mar 1, 1978·Clinics in Endocrinology and Metabolism·J M Friedman, P J Fialkow
Aug 1, 1978·Tissue Antigens·S H ChanJ S Cheah
Apr 1, 1976·The Journal of Experimental Medicine·A TingP I Terasaki
Aug 24, 1974·Lancet·B R Smith, R Hall
May 24, 1980·Lancet·A M McGregorP J Dewar

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Citations

Feb 1, 1990·Clinical Endocrinology·S RatanachaiyavongA M McGregor
Jan 1, 1993·Thyroid : Official Journal of the American Thyroid Association·L Wartofsky

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