Abstract
The immunoreactivity of thyroid transcription factor-1 (TTF-1) is a very specific marker for lung and thyroid neoplasms; the expression of TTF-1 has also been demonstrated in extrapulmonary carcinomas. We examined the expression of TTF-1 in 15 intestinal-type adenocarcinomas of the extrahepatic bile duct. We then compared the expression to TTF-1 staining with other immunohistochemical markers including cytokeratin (CK) 7, CK20, caudal-type homeobox transcription factor 2 (CDX2), Napsin A, and MUC2. We additionally compared the clinicopathological prognostic factors with the TTF-1 expression status. Nuclear TTF-1 staining was detected in 2 cases (13.3%), and Napsin A was positive in the same 2 cases (13.3%). All cases were positive for CK20, CDX2, and MUC2; 5 cases were positive for CK7. There was no correlation between TTF-1 expression and the clinicopathological characteristics. To avoid potential pitfalls, TTF-1 should be interpreted in conjunction with the clinical setting, histology, and the results of markers such as CK7, CK20, Napsin A, and CDX2. This report is the first of TTF-1 positivity in adenocarcinomas from the extrahepatic biliary tract.
References
Feb 1, 1992·Molecular and Cellular Biology·H Francis-LangR Di Lauro
Mar 24, 1995·The Journal of Biological Chemistry·M D BrunoT R Korfhagen
Feb 1, 1996·Hybridoma·A HolzingerJ A Whitsett
Jun 22, 1999·Human Pathology·A KhoorP T Cagle
Jun 8, 2001·The American Journal of Surgical Pathology·A M OliveiraR V Lloyd
Apr 11, 2002·Virchows Archiv : an International Journal of Pathology·Michael ScarpatettiHelmut H Popper
Apr 17, 2002·Virchows Archiv : an International Journal of Pathology·Josef Zamecnik, Roman Kodet
Jan 28, 2003·The American Journal of Surgical Pathology·M BarbareschiC Doglioni
Feb 4, 2003·Archives of Pathology & Laboratory Medicine·Pablo A Bejarano, Fathema Mousavi
Feb 27, 2003·The American Journal of Surgical Pathology·Robert W WerlingAllen M Gown
May 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Min Jong LeeMihi Yang
Feb 22, 2005·Applied Immunohistochemistry & Molecular Morphology : AIMM·Robert M MazziottaMahesh Mansukhani
Oct 10, 2007·Archives of Pathology & Laboratory Medicine·Seog-Yun ParkGyeong Hoon Kang
Dec 17, 2009·Human Pathology·Sawako FujiwaraYasushi Yatabe
Jun 13, 2012·Histopathology·Anne Marie QuinnPhilip Hasleton
May 17, 2013·Diagnostic Pathology·Tor A KlingenLars A Akslen
Aug 1, 2013·Archives of Pathology & Laboratory Medicine·Kanwaijit S AulakhV O Speights
Oct 12, 2013·Histopathology·Yun-Bi NiGary M Tse
Nov 26, 2013·Histopathology·Aaron ErvineW Glenn McCluggage
Jan 15, 2014·The American Journal of Surgical Pathology·Lea F SurreyEmma E Furth
Sep 24, 2014·Applied Immunohistochemistry & Molecular Morphology : AIMM·Enrico PegoloCarla Di Loreto