Thyroid transcription factor 1 (TTF-1) and p63 expression in two primary thyroid papillary carcinomas of branchial cleft cysts.

Virchows Archiv : an International Journal of Pathology
S LanzafameA Cappellani

Abstract

Malignant lateral cervical cysts can be related to metastatic tumors or rarely to primary thyroid carcinoma arising in branchial cleft cysts. This study evaluates the expression of thyroid-associated transcription factor-1 (TTF-1) and p63 in three branchial cleft cysts and in two primary thyroid papillary carcinoma of branchial cleft cysts. TTF-1 was negative in the nuclei of the lining epithelia of branchial cleft cysts, but positive in the adjacent normal thyroid tissue, while TTF-1 was positive in the nuclei of the lining epithelia and in the nuclei of the papillae and follicles in branchial cleft cysts with ectopic thyroid carcinoma. P63 was positive in the nuclei of the lining epithelia of branchial cleft cysts, but negative in the adjacent normal thyroid tissue. Papillary thyroid carcinoma of branchial cleft cysts displayed p63-positive foci. In conclusion, our results demonstrate that TTF-1 cannot distinguish between primary and metastatic tumors of branchial cleft cysts. The detection of p63 in papillary thyroid carcinomas of branchial cleft cysts could suggest that p63 contributes to the onset of this tumor. It is really important to evaluate if the case has a metastatic derivation or represents papillary thyroid carci...Continue Reading

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Citations

Nov 17, 2007·The Journal of Laryngology and Otology·K O DevaneyC Suárez
Mar 17, 2010·The Journal of Laryngology and Otology·A J C HazenbergF Hoppe
Jan 19, 2013·Current Opinion in Otolaryngology & Head and Neck Surgery·Paula T Bradley, Patrick J Bradley
Nov 18, 2008·The American Journal of Surgical Pathology·Michele BiscegliaJuan Rosai
Jan 15, 2009·Folia Histochemica Et Cytobiologica·El Ali ZiadMarian Grzymislawski
Jan 15, 2008·The Kaohsiung Journal of Medical Sciences·Hung-Sheng ChiKa-Wo Lee
Feb 10, 2012·Journal of the Korean Surgical Society·Jin Seong ChoYoung Jong Jegal
Aug 2, 2013·Ear, Nose, & Throat Journal·Mustafa SagitUnsal Han

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