PMID: 698038Aug 1, 1978Paper

Thyroid tumours in rats and hepatomas in mice after griseofulvin treatment

British Journal of Cancer
M Rustia, P Shubik

Abstract

Griseofulvin, an antibiotic used to treat dermatophystosis, was tested for carcinogenicity in mice, rats and hamsters. Three groups of mice and rats were given the drug in powdered diet in alternating 5-week periods for life, at dose levels of 3.0%, 1.5% and 0.3% (mice) and 2.0%, 1.0% and 0.2% (rats). A group of mice and 3 groups of hamsters received continuous daily treatment for life with griseofulvin at 3.0%, 1.5%, 0.3% and 0.1% dose levels respectively. A significant incidence of hepatic tumours was observed at the 2 higher treatment levels in mice. Also, statistically significant rates (P less than or equal to 0.001 and/or P less than or equal to 0.020) of thyroid tumours, indicating a dose-response, were recorded in male rats at the 2.0%, 1.0%, and 0.2% dose levels, and in females at the 2.0% and 1.0% dose levels. Hamsters did not develop neoplasms in response to treatment at any level.

Citations

Nov 5, 1997·Critical Reviews in Toxicology·S KnasmüllerR Schulte-Hermann
Dec 18, 2001·Teratogenesis, Carcinogenesis, and Mutagenesis·K LabayP Sanders
Jan 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S W French
Aug 10, 2018·Toxicology Research·Andrew G Smith, John R Foster
Mar 1, 1981·Cancer·R Hoover, J F Fraumeni
Mar 1, 1988·Mutation Research·L De Carli, L Larizza

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