Thyrolipoma and thyrolipomatosis: 5 case reports and historical review of the literature

Annals of Diagnostic Pathology
Yimin GeAlberto G Ayala

Abstract

Because thyrolipoma (adenolipoma of thyroid) and thyrolipomatosis (diffuse lipomatosis of thyroid) are distinctively rare conditions with only few cases reported in the literature, we are reporting 5 additional cases. All the 5 patients were adult females, with ages from 38 to 79 years, who presented with thyroid masses. Four of the patients had normal thyroid function tests and one had mild hypothyroidism. All patients received partial or total thyroidectomy. The thyroid specimens showed either circumscribed yellow-tan masses (cases 1, 2, and 3) or diffuse yellow-brown discoloration (cases 4 and 5). Histologic examination revealed abundant mature fat infiltrating the affected thyroid tissue in 3 distinct patterns: (1) fat infiltration limited to follicular adenomas (thyrolipoma); (2) fat diffusely infiltrating throughout the thyroid gland (thyrolipomatosis); or (3) fat infiltration involving both follicular adenoma and their surrounding thyroid tissue. Because of the rarity of thyroid fat-containing lesions, confusion in differential diagnosis may occasionally occur. It is important to be aware during frozen section that these lesions may present as extrathyroidal nodules, which can be radioactive on intraoperative scan for pa...Continue Reading

References

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Citations

Aug 16, 2013·Ultrasound Quarterly·Ryan Lo, Carolyn Donaldson
Aug 15, 2015·Indian Journal of Pathology & Microbiology·Hariharanadha Sarma NandyalaSudheer Kumar Katamala
Jun 3, 2016·Endocrinology, Diabetes & Metabolism Case Reports·Soledad BellMaría Fabiana Russo Picasso
Jan 28, 2018·Journal of Ultrasound·Monica PennisiGiuliana Costanzo
Nov 18, 2015·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Jin Woo ChoiKyoung Sik Park
Aug 5, 2020·International Journal of Surgical Pathology·K K W YuenW Cheuk
Sep 10, 2014·BMJ Case Reports·Nicholas FitzpatrickRichard Lewis
Jun 8, 2017·Molecular and Clinical Oncology·Mitsuaki IshidaKoji Tsuta
Oct 19, 2017·ANZ Journal of Surgery·Anne Stanaway, Tracey Lam
Dec 30, 2020·Interactive Cardiovascular and Thoracic Surgery·Giuseppe MangiameliFrançoise Le Pimpec-Barthes
Jan 26, 2021·Annales de pathologie·Sirine AyadiIlhem Charfeddine
Jun 29, 2021·The American Surgeon·Rosa Martí-FernándezAntonio Ferrández-Izquierdo

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