THYROSIM App for Education and Research Predicts Potential Health Risks of Over-the-Counter Thyroid Supplements

Thyroid : Official Journal of the American Thyroid Association
Simon X HanJoseph J DiStefano Iii

Abstract

Computer simulation tools for education and research are making increasingly effective use of the Internet and personal devices. To facilitate these activities in endocrinology and metabolism, a mechanistically based simulator of human thyroid hormone and thyrotropin (TSH) regulation dynamics was developed and further validated, and it was implemented as a facile and freely accessible web-based and personal device application: the THYROSIM app. This study elucidates and demonstrates its utility in a research context by exploring key physiological effects of over-the-counter thyroid supplements. THYROSIM has a simple and intuitive user interface for teaching and conducting simulated "what-if" experiments. User-selectable "experimental" test-input dosages (oral, intravenous pulses, intravenous infusions) are represented by animated graphical icons integrated with a cartoon of the hypothalamic-pituitary-thyroid axis. Simulations of familiar triiodothyronine (T3), thyroxine (T4), and TSH temporal dynamic responses to these exogenous stimuli are reported graphically, along with normal ranges on the same single interface page; and multiple sets of simulated experimental results are superimposable to facilitate comparative analyses. T...Continue Reading

References

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Jan 4, 2007·Thyroid : Official Journal of the American Thyroid Association·Marisa EisenbergJoseph J DiStefano
Oct 11, 2008·Thyroid : Official Journal of the American Thyroid Association·Marisa EisenbergJoseph J DiStefano
Feb 5, 2009·Thyroid : Official Journal of the American Thyroid Association·Marisa Eisenberg, Joseph J Distefano
Nov 11, 2010·Thyroid : Official Journal of the American Thyroid Association·Marisa C EisenbergJoseph J DiStefano
May 15, 2012·Thyroid : Official Journal of the American Thyroid Association·Rotem Ben-ShacharJoseph J DiStefano
Jun 14, 2013·Thyroid : Official Journal of the American Thyroid Association·Grace Y KangVictor J Bernet

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Citations

Jul 5, 2016·Frontiers in Endocrinology·Johannes W DietrichRudolf Hoermann
Mar 13, 2020·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Michael S IrwigIrina Bancos
Dec 6, 2019·Frontiers in Endocrinology·Joseph DiStefano, Jacqueline Jonklaas
Jun 21, 2018·Frontiers in Endocrinology·Johannes W DietrichRudolf Hoermann

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Software Mentioned

Kindle
Amazon Kindle
Mozilla Firefox
Nook
OCTAVE
THYROSIM
Internet Explorer
Samsung Android
Android OS
Apple Safari

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