Thyrotoxicosis after iodine fortification. A 21-year Danish population-based study

Clinical Endocrinology
Mads PetersenInge Bülow Pedersen

Abstract

Monitoring the influence of cautious iodine fortification (IF) on the incidence rate of overt thyrotoxicosis in Denmark with formerly frequent multinodular toxic goitre. A 21-year (1997-2017) prospective population-based study identified all new cases of overt biochemical thyrotoxicosis in two open cohorts: a Western cohort with moderate iodine deficiency (ID) and an Eastern cohort with mild ID (total n = 533 969 by 1 January 1997). A diagnostic algorithm was applied to all thyroid function tests performed within the study areas. Mandatory IF of salt was initiated in mid-2000 (13 ppm). This study is a part of DanThyr. The standardized incidence rate (SIR) of thyrotoxicosis at baseline (1997-1998) was 128.5/100.000/year in the cohort with moderate ID and 80.1 in the cohort with mild ID. SIR increased markedly in both cohorts during the initial years of IF (moderate/mild ID: +39/+52% in 2000-2001/2004-2005) and subsequently decreased to baseline level (mild ID) or below (moderate ID) by 2008. The decline was due to a marked decrease in the incidence rate among elderly subjects and a moderate decrease among the middle aged. The follow-up period for the mildly iodine deficient cohort was restricted to 2008. A continuous decline in ...Continue Reading

References

Jun 12, 1971·The Medical Journal of Australia·R J Connolly
Jan 1, 1983·Medicine·J E Fradkin, J Wolff
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·F Delange
Oct 1, 1993·The Journal of Clinical Endocrinology and Metabolism·K M PedersenP L Johannesen
Sep 1, 1996·International Journal of Food Sciences and Nutrition·L B RasmussenL Ovesen
Mar 10, 1998·Thyroid : Official Journal of the American Thyroid Association·J B StanburyG Medeiros-Neto
Jun 9, 2001·Thyroid : Official Journal of the American Thyroid Association·P LaurbergS Andersen
Jul 20, 2006·The Journal of Clinical Endocrinology and Metabolism·Inge Bülow PedersenLone Banke Rasmussen
Jul 27, 2006·European Journal of Endocrinology·Peter LaurbergPernille Vejbjerg
Apr 16, 2009·The Journal of Clinical Endocrinology and Metabolism·Charlotte CerqueiraTorben Jørgensen
Jan 20, 2010·European Journal of Endocrinology·Charlotte CerqueiraTorben Jørgensen
Feb 23, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Peter LaurbergAllan Carlé
Mar 2, 2011·European Journal of Endocrinology·Allan CarléPeter Laurberg
Jun 12, 2013·Thyroid : Official Journal of the American Thyroid Association·Allan CarléPeter Laurberg
Nov 26, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Lone B RasmussenLars Ovesen
Sep 19, 2014·The Journal of Clinical Endocrinology and Metabolism·Anne KrejbjergPeter Laurberg
Oct 31, 2014·The British Journal of Nutrition·Lone B RasmussenLars Ovesen
Jan 17, 2015·The Lancet. Diabetes & Endocrinology·Michael B Zimmermann, Kristien Boelaert

❮ Previous
Next ❯

Citations

Sep 8, 2019·Nature Reviews. Endocrinology·Michael B Zimmermann
Dec 15, 2018·The Journal of Clinical Endocrinology and Metabolism·Mads PetersenInge Bülow Pedersen
Mar 21, 2019·Annals of the New York Academy of Sciences·Jessica FarebrotherMaria Andersson
Aug 11, 2019·Clinical Endocrinology·Mads PetersenAllan Carlé
Aug 28, 2020·Thyroid : Official Journal of the American Thyroid Association·Monika SchaffnerUrsula Rochau
Apr 30, 2021·Immunologic Research·Claudia TetiMarcello Bagnasco
Jun 5, 2021·The British Journal of Nutrition·Herborg Líggjasardóttir JohannesenAnna Sofía Veyhe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.