Thyrotoxicosis in patients with COVID-19: the THYRCOV study

European Journal of Endocrinology
Andrea LaniaGherardo Mazziotti

Abstract

This study assessed thyroid function in patients affected by the coronavirus disease-19 (COVID-19), based on the hypothesis that the cytokine storm associated with COVID-19 may influence thyroid function and/or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may directly act on thyroid cells, such as previously demonstrated for SARS-CoV-1 infection. This single-center study was retrospective and consisted in evaluating thyroid function tests and serum interleukin-6 (IL-6) values in 287 consecutive patients (193 males, median age: 66 years, range: 27-92) hospitalized for COVID-19 in non-intensive care units. Fifty-eight patients (20.2%) were found with thyrotoxicosis (overt in 31 cases), 15 (5.2%) with hypothyroidism (overt in only 2 cases), and 214 (74.6%) with normal thyroid function. Serum thyrotropin (TSH) values were inversely correlated with age of patients (rho -0.27; P < 0.001) and IL-6 (rho -0.41; P < 0.001). In the multivariate analysis, thyrotoxicosis resulted to be significantly associated with higher IL-6 (odds ratio: 3.25, 95% confidence interval: 1.97-5.36; P < 0.001), whereas the association with age of patients was lost (P = 0.09). This study provides first evidence that COVID-19 may be associat...Continue Reading

Citations

Nov 27, 2020·Reviews in Endocrine & Metabolic Disorders·Lorenzo ScappaticcioPierpaolo Trimboli
Nov 4, 2020·The Journal of Clinical Endocrinology and Metabolism·David Tak Wai LuiKaren Siu Ling Lam
Oct 23, 2020·Journal of Medical Virology·Hugo R RosenTrevor Angell
Nov 13, 2020·The Journal of Clinical Endocrinology and Metabolism·Bernard KhooWaljit S Dhillo
Jan 12, 2021·Endocrinology·Wenjie ChenJianyong Lei
Feb 10, 2021·Journal of Endocrinological Investigation·L CroceL Chiovato
Nov 26, 2020·American Journal of Physiology. Endocrinology and Metabolism·Narasimhan KothandaramanMelvin Khee Shing Leow
Feb 16, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Karen Tsai, Angela M Leung
Nov 5, 2020·Journal of the Endocrine Society·Michelle D LundholmNorma Lopez
Nov 4, 2020·Journal of Endocrinological Investigation·W GaoX Zhou
Mar 4, 2021·Archives of Physiology and Biochemistry·Adel Abdel-Moneim, Ahmed Hosni
Mar 6, 2021·Journal of Endocrinological Investigation·G MazziottiUNKNOWN Humanitas COVID19 Task Force
Feb 6, 2021·Endocrinology·Wenjie ChenJianyong Lei
Mar 9, 2021·Endocrinology and Metabolism·Eun Kyung Lee, Young Joo Park
Mar 18, 2021·Clinical and Translational Imaging : Reviews in Nuclear Medicine and Molecular Imaging·Luca GiovanellaDesiree Deandreis
Mar 26, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Luca GiovanellaDesiree Deandreis
Mar 26, 2021·Journal of Endocrinological Investigation·G LiscoV Triggiani
Nov 13, 2020·Endocrine Journal·Shinsuke MizunoNobuhiro Komiya
Mar 29, 2021·Endocrine·Philippe Caron
Apr 5, 2021·Diabetes & Metabolic Syndrome·Ritwik GhoshJulián Benito-León
Apr 16, 2021·Journal of Investigative Medicine High Impact Case Reports·Sherin Elsa MathewsAmie Ogunsakin
Apr 28, 2021·Nature Reviews. Rheumatology·Manuel Ramos-CasalsXavier Mariette
May 1, 2021·International Journal of Environmental Research and Public Health·Katarzyna AdamczewskaRenata Stawerska
Mar 3, 2021·Clinical Endocrinology·Dorota DworakowskaAshley B Grossman
May 6, 2021·Reviews in Endocrine & Metabolic Disorders·Magdalena Stasiak, Andrzej Lewiński
May 12, 2021·Ear, Nose, & Throat Journal·Ali Seyed Resuli, Muzaffer Bezgal
May 14, 2021·Frontiers in Endocrinology·Eleonore Fröhlich, Richard Wahl
Mar 4, 2021·International Journal of Clinical Practice·Mehmet Güven, Hamza Gültekin
May 22, 2021·Expert Review of Clinical Immunology·Rosaria Maddalena RuggeriLuca Giovanella
May 29, 2021·Endocrine·Alessandro PizzocaroUNKNOWN Humanitas COVID-19 Task force
Jun 9, 2021·Journal of Endocrinological Investigation·R BaldelliP Zuppi
Jun 10, 2021·Endocrine·Avaniyapuram Kannan Murugan, Ali S Alzahrani
Jul 1, 2021·Journal of the Endocrine Society·Leonidas H Duntas, Jacqueline Jonklaas
Jul 3, 2021·Journal of Clinical Medicine·Giuseppe LiscoVincenzo Triggiani
Jun 29, 2021·Clinical Case Reports·Magdy Mohamed AllamMohamed Aly Abdelhamid
Jul 1, 2021·Journal of Endocrinological Investigation·A M PomaF Basolo
Jul 13, 2021·AACE Clinical Case Reports·Angela N RaoRuchi Gaba
Jul 20, 2021·Frontiers in Endocrinology·Hidefumi Inaba, Toru Aizawa
Jul 17, 2021·Endocrinology, Diabetes & Metabolism·Ryan MillerSowmya Krishnan
Jul 11, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Stelios F AssimakopoulosMarina A Michalaki
Jul 28, 2021·Thyroid : Official Journal of the American Thyroid Association·Fabyan Esberard de Lima BeltrãoHelton Estrela Ramos

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