PMID: 6105023Feb 1, 1980Paper

Thyrotrophin binding inhibiting immunoglobulins in Graves' disease before, during and after antithyroid therapy, and its relation to long-acting thyroid stimulator

Clinical Endocrinology
R DocterG Hennemann

Abstract

Thyrotrophin binding inhibiting immunoglublins (TBII) were measured in twenty-five patients with unequivocal hyperthyroid Graves' disease with a radioreceptor assay for TSH before, during and the end of treatment with antihyroid drugs and triiodothyronine. To assess the outcome of this therapy patients were followed for 10--90 months (mean 63 months). Before treatment there was significant correlation between TBII activity and serum thyroxine (r = -0.48, P less 0.05) and between TBII activated and 24 hour 131I thyroid uptake (r = -0.57, P less than 0.01). No relationship was found between TBII activated and 20 min, 4 hour and 48 hour 131I thyroid uptakes before institution of therapy. During treatment a significant correlation between TBII index and 20 min 131I thyroid uptake was found (r = -0.55, P less than 0.001). Both before and during treatment there was a significant correlation between TBII and LATS activity (r = -0.65, P less than 0.001). From the magnitude of this correlation coefficient it can be concluded that related, although not the same immunoglobulins, are measured with the two assay techniques. It is not possible to predict the occurrence of a relapse from the presence or absence of TBII activity at the end of ...Continue Reading

References

Oct 1, 1978·Endocrinology·M Zakarija, J M McKenzie
Aug 1, 1978·The Journal of Clinical Endocrinology and Metabolism·M Zakarija, J M McKenzie
Oct 1, 1978·The Journal of Clinical Endocrinology and Metabolism·M Zakarija, J M McKenzie
Apr 1, 1976·The Journal of Clinical Endocrinology and Metabolism·J M McKenzie, M Zakarija
May 1, 1978·The Journal of Clinical Endocrinology and Metabolism·J O'DonnellR Volpé
Aug 1, 1978·The Journal of Clinical Endocrinology and Metabolism·H SchleusenerK W Wenzel
Aug 1, 1978·The Journal of Clinical Endocrinology and Metabolism·C R StrakoschJ R Wall
Jan 27, 1977·The New England Journal of Medicine·D H SolomonF J Smith
Sep 1, 1976·The Journal of Clinical Endocrinology and Metabolism·R ClagueR Hall
Feb 1, 1976·The Journal of Clinical Endocrinology and Metabolism·J OrgiazziD H Solomon
Jun 1, 1975·The Journal of Clinical Endocrinology and Metabolism·G HennemannJ Van Zijl
Sep 1, 1972·Metabolism: Clinical and Experimental·J M McKenzie
Aug 24, 1974·Lancet·B R Smith, R Hall
Sep 30, 1967·Lancet·W D AlexanderP McGill
Nov 1, 1974·The Journal of Clinical Endocrinology and Metabolism·D D AdamsR D Stewart
Oct 1, 1970·The Journal of Clinical Endocrinology and Metabolism·I J ChopraN P Limberg

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Citations

Jan 1, 1993·Rheumatology International·R T TsaiC Y Chen
Jan 1, 1983·Molecular Aspects of Medicine·N R FaridJ C Bear
Dec 9, 1982·The New England Journal of Medicine·C R StrakoschR Volpé
Jun 1, 1984·Journal of Endocrinological Investigation·J HensenH Schleusener
Jan 1, 1988·The Korean Journal of Internal Medicine·M S LeeC Y Cha
Jan 1, 1988·The Korean Journal of Internal Medicine·W Y ChoI M Ahn
Jun 3, 2004·The Journal of Clinical Investigation·Takao AndoTerry F Davies
Sep 1, 1981·Scandinavian Journal of Clinical and Laboratory Investigation·H Bliddal
Jan 1, 1988·Critical Reviews in Clinical Laboratory Sciences·S D FlynnS T Bigos
Jan 1, 1986·Critical Reviews in Clinical Laboratory Sciences·A P Dalmasso
Jun 1, 1986·Journal of Endocrinological Investigation·J H RomaldiniN Bromberg
Jan 2, 1986·Klinische Wochenschrift·E SchifferdeckerK Schöffling
Dec 1, 1986·Metabolism: Clinical and Experimental·T W De BruinR S Brown

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