PMID: 2105105Jan 1, 1990Paper

Thyrotropin and prolactin response to thyrotropin-releasing hormone in depressed and nondepressed alcoholic men

Biological Psychiatry
M L WillenbringW Dorus

Abstract

Thyrotropin-releasing hormone (TRH) stimulation tests were performed on 81 alcoholic men after at least 3 weeks of abstinence. Subjects were given 500 micrograms of TRH intravenously, and thyroid-stimulating hormone (TSH) and prolactin (PRL) were measured at baseline, and then 15 and 30 min later. Comparisons were made among alcoholics with (n = 27) and without (n = 54) a lifetime history of depression as determined by the Diagnostic Interview Schedule. Nine nondepressed, nonalcoholic subjects served as controls. Alcoholics with or without a depression history did not differ from each other or from control in TSH or PRL response area under the curve. Blunted TSH responses were present in 10 (12%) of the alcoholics and none of the controls when blunting was defined as a delta max TSH less than 5 microU/ml. When blunting was defined as a delta max TSH less than 7 microU/ml, 18 (22%) of the alcoholics and 1 (1%) of the controls were blunted. Conversely, 2 (2.5%) of the alcoholics had a delta max TSH greater than 32 microU/ml. All subjects were clinically euthyroid. Contrary to expectation, depressed subjects were slightly less likely to show blunted responses than nondepressed subjects. No relationship was found between neuroendoc...Continue Reading

References

Jul 1, 1978·Alcoholism, Clinical and Experimental Research·D H van Thiel, R Lester
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Jun 1, 1961·Archives of General Psychiatry·A T BECKJ ERBAUGH

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Citations

Oct 1, 1995·Alcoholism, Clinical and Experimental Research·J C GarbuttG A Mason
Dec 1, 1992·The Australian and New Zealand Journal of Psychiatry·J D Sellman, P R Joyce

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