Thyrotropin as an independent factor of renal function and chronic kidney disease in normoglycemic euthyroid adults

Endocrine Research
Ming-Tsung SunYi-Jen Hung

Abstract

The relationship between thyroid status and renal function has been well characterized. However, renal function is affected by various factors, including sex and dysglycemia. Because these studies have yet to be undertaken in a normoglycemic population, this study sought to explore the association between thyroid and renal function in large population of normoglycemic euthyroid adults. Population-based cross-sectional survey. A total of 8,418 normoglycemic euthyroid participants were recruited after excluding individuals with thyroid dysfunction (thyrotropin, TSH < 0.47 mU/L, TSH ≥ 5.0 mU/L) or dysglycemia (fasting glucose ≥100 mg/dL). Anthropometric measurements were collected, and creatinine, TSH, and fasting glucose levels were evaluated. Renal function was determined by the estimated glomerular filtration rate (e-GFR) calculated using the simplified Modification of Diet in Renal Disease formula. TSH levels were inversely correlated with e-GFR. After adjustment for confounding factors, multivariate analysis revealed that TSH remained an independent factor of e-GFR in both genders (beta = -1.512 in males and -1.685 in females), and TSH was an independent factor of chronic kidney disease (OR = 1.28, 95% CI = 1.021-1.604). TSH ...Continue Reading

References

Feb 1, 1988·The American Journal of Physiology·A A McDonoughC A Schmitt
Mar 1, 1989·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J D CongerD M Gillum
Jan 1, 1984·Contributions to Nephrology·E M KapteinS G Massry
Oct 1, 1994·Journal of Cellular Physiology·J P CanavanD F Goldspink
Jun 10, 1993·The New England Journal of Medicine·D M Nathan
Apr 10, 1996·JAMA : the Journal of the American Medical Association·R A Rettig
Oct 1, 1996·Thyroid : Official Journal of the American Thyroid Association·K OjamaaI Klein
Apr 20, 1999·Mineral and Electrolyte Metabolism·G CapassoN G De Santo
Jan 5, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gunter WolfFuad N Ziyadeh
Nov 28, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Stefan MoellerGail Brown
Sep 24, 2004·The New England Journal of Medicine·Nagesh S AnavekarMarc A Pfeffer
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Oct 9, 2004·Clinical Chemistry·Mindy L Rawlins, William L Roberts
Mar 9, 2005·Kidney International. Supplement·Robert C Atkins
Apr 6, 2005·Clinical Endocrinology·Jan G den HollanderArie Berghout
Sep 20, 2005·Annals of Clinical Biochemistry·Edmund J LambUNKNOWN Clinical Sciences Reviews Committee of the Association for Clinical Biochemistry
Feb 23, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kitty J Jager, Paul C W van Dijk
Jun 25, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·John G Toffaletti, Elizabeth H McDonnell
Jan 10, 2009·General and Comparative Endocrinology·Ingrid van Hoek, Sylvie Daminet
Mar 3, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Rajiv Agarwal, Robert P Light
Mar 17, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Adam Whaley-ConnellUNKNOWN KEEP Investigators

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Citations

Apr 16, 2013·European Journal of Endocrinology·Akihiro TsudaEiji Ishimura
Jan 2, 2013·European Journal of Internal Medicine·Roger K SchindhelmSuat Simsek
Dec 24, 2015·International Journal of Endocrinology·Jingcheng WuYongde Peng
Oct 30, 2015·Journal of Endocrinological Investigation·Mariadelina SimeoniGiorgio Fuiano
Feb 28, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Connie M RheeKamyar Kalantar-Zadeh
Aug 18, 2018·Annals of Clinical Biochemistry·Gautam DasOnyebuchi Okosieme
Nov 20, 2016·Reviews in Endocrine & Metabolic Disorders·Pedro IglesiasJuan José Díez
Jan 9, 2020·Thyroid : Official Journal of the American Thyroid Association·Christina EllervikDaniel I Chasman
Mar 25, 2020·Endocrinology and Metabolism·Mijin KimIn Joo Kim
Jan 23, 2013·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Yicong YeShuyang Zhang
Mar 25, 2019·Endocrine·Ezgi SönmezKursat Dal
Jun 20, 2017·Frontiers in Endocrinology·Domenico SantoroSalvatore Benvenga

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